Volume 133, Issue 41 p. 22258
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Innentitelbild: Molecular Basis for Two Stereoselective Diels–Alderases that Produce Decalin Skeletons (Angew. Chem. 41/2021)

Dr. Keisuke Fujiyama

Dr. Keisuke Fujiyama

Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho, Minami, Tottori, 680-8552 Japan

Current address: Dormancy and Adaptation Research Unit, RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa, 230-0045 Japan

These authors contributed equally to this work.

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Dr. Naoki Kato

Corresponding Author

Dr. Naoki Kato

Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Research Science, 2-1 Hirosawa, Wako, Saitama, 351-0198 Japan

Faculty of Agriculture, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101 Japan

These authors contributed equally to this work.

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Dr. Suyong Re

Dr. Suyong Re

Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minami-machi, Chuo-ku, Kobe, Hyogo, 650-0047 Japan

Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health, and Nutrition, 7-6-8, Saito-Asagi, Ibaraki, Osaka, 567-0085 Japan

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Kiyomi Kinugasa

Kiyomi Kinugasa

Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Research Science, 2-1 Hirosawa, Wako, Saitama, 351-0198 Japan

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Dr. Kohei Watanabe

Dr. Kohei Watanabe

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan

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Dr. Ryo Takita

Dr. Ryo Takita

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan

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Dr. Toshihiko Nogawa

Dr. Toshihiko Nogawa

Chemical Biology Research Group, RIKEN Center for Sustainable Research Science, 2-1 Hirosawa, Wako, Saitama, 351-0198 Japan

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Dr. Tomoya Hino

Dr. Tomoya Hino

Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho, Minami, Tottori, 680-8552 Japan

Center for Research on Green Sustainable Chemistry, Tottori University, 4-101 Koyama-cho, Minami, Tottori, 680-8552 Japan

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Dr. Hiroyuki Osada

Dr. Hiroyuki Osada

Chemical Biology Research Group, RIKEN Center for Sustainable Research Science, 2-1 Hirosawa, Wako, Saitama, 351-0198 Japan

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Dr. Yuji Sugita

Dr. Yuji Sugita

Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minami-machi, Chuo-ku, Kobe, Hyogo, 650-0047 Japan

Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama, 351-0198 Japan

Computational Biophysics Research Team, RIKEN Center for Computational Science, 7-1-26 Minatojima-minami-machi, Chuo-ku, Kobe, Hyogo, 650-0047 Japan

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Dr. Shunji Takahashi

Corresponding Author

Dr. Shunji Takahashi

Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Research Science, 2-1 Hirosawa, Wako, Saitama, 351-0198 Japan

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Prof. Shingo Nagano

Corresponding Author

Prof. Shingo Nagano

Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho, Minami, Tottori, 680-8552 Japan

Center for Research on Green Sustainable Chemistry, Tottori University, 4-101 Koyama-cho, Minami, Tottori, 680-8552 Japan

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First published: 09 August 2021

Graphical Abstract

Bindung einer linksdrehenden oder rechtsdrehenden Faltung mit Flip: Eine lineare Kohlenwasserstoffkette, die ein Dien und ein Dienophil enthält, wird gefaltet und durch intramolekulare [4+2]-Cycloaddition in ein Dekalingrundgerüst umgewandelt. Die Substrate falten entgegengesetzt, binden aber in der gleichen Ausrichtung in die Taschen eines Paares von Diels-Alderasen, um Dekalingerüste mit enantiomeren Konformationen zu liefern, wie Naoki Kato, Shunji Takahashi und Shingo Nagano im Forschungsartikel auf S. 22575 berichten.

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