Angewandte Chemie
Volume 131, Issue 40 p. 14527
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Innenrücktitelbild: Fluorescent Isoindole Crosslink (FlICk) Chemistry: A Rapid, User-friendly Stapling Reaction (Angew. Chem. 40/2019)

Mihajlo Todorovic, 

Mihajlo Todorovic

Chemistry Department, UBC, 2036 Main Mall, Vancouver, B.C., V6T1Z1 Canada

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Katerina D. Schwab, 

Katerina D. Schwab

Chemistry Department, UBC, 2036 Main Mall, Vancouver, B.C., V6T1Z1 Canada

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Dr. Jutta Zeisler, 

Dr. Jutta Zeisler

B.C. Cancer Agency Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3 Canada

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Dr. Chengcheng Zhang, 

Dr. Chengcheng Zhang

B.C. Cancer Agency Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3 Canada

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Prof. Dr. Francois Bénard, 

Prof. Dr. Francois Bénard

B.C. Cancer Agency Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3 Canada

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Prof. Dr. David M. Perrin, 

Corresponding Author

Prof. Dr. David M. Perrin

Chemistry Department, UBC, 2036 Main Mall, Vancouver, B.C., V6T1Z1 Canada

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First published: 23 August 2019
https://doi.org/10.1002/ange.201909719

Graphical Abstract

FlICk-Chemie (“fluorescent isoindole crosslink”) wird von D. M. Perrin et al. in der Zuschrift auf S. 14258 ff. eingeführt, um cyclische Peptide mit fluoreszierendem Twist herzustellen. Die Reaktion zwischen ortho-Phthalaldehyden sowie amin- und thiolhaltigen Seitenketten in Peptiden erzeugt Isoindol-geheftete, bioaktive, mono- und bicyclische Peptide mit abstimmbaren photophysikalischen Eigenschaften unter milden, metallfreien Bedingungen.

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