Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.

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References

1E. Unger, T. Porter, J. Lindner, P. Grayburn, Adv. Drug Delivery Rev. 2014, 72, 110–126.
10.1016/j.addr.2014.01.012
CAS PubMed Web of Science® Google Scholar
2S. R. Sirsi, M. A. Borden, Adv. Drug Delivery Rev. 2014, 72, 3–14.
10.1016/j.addr.2013.12.010
CAS PubMed Web of Science® Google Scholar
3S. Unnikrishnan, A. L. Klibanov, Am. J. Roentgenol. 2012, 199, 292–299.
10.2214/AJR.12.8826
PubMed Web of Science® Google Scholar
4M. B. Linder, Curr. Opin. Colloid Interface Sci. 2009, 14, 356–363.
10.1016/j.cocis.2009.04.001
CAS Web of Science® Google Scholar
5
5aA. Schulz, B. M. Liebeck, D. John, A. Heiss, T. Subkowski, A. Böker, J. Mater. Chem. 2011, 21, 9731–9736;
10.1039/c1jm10662g
CAS Web of Science® Google Scholar
5bR. Milani, E. Monogioudi, M. Baldrighi, G. Cavallo, V. Arima, L. Marra, A. Zizzari, R. Rinaldi, M. Linder, G. Resnati, P. Metrangolo, Soft Matter 2013, 9, 6505–6514;
10.1039/c3sm51262b
CAS Web of Science® Google Scholar
5cC. Pigliacelli, A. D′Elicio, R. Milani, G. Terraneo, G. Resnati, F. Baldelli Bombelli, P. Metrangolo, J. Fluorine Chem. 2015, 177, 62–69.
10.1016/j.jfluchem.2015.02.004
CAS Web of Science® Google Scholar
6N. A. Alexandrov, K. G. Marinova, T. D. Gurkov, K. D. Danov, P. A. Kralchevsky, S. D. Stoyanov, T. B. J. Blijdenstein, L. N. Arnaudov, E. G. Pelan, A. Lips, J. Colloid Interface Sci. 2012, 376, 296–306.
10.1016/j.jcis.2012.03.031
CAS PubMed Web of Science® Google Scholar
7T. van Rooij, Y. Luan, G. Renaud, A. F. W. van der Steen, M. Verluis, N. de Jong, K. Kooiman, Ultrasound Med. Biol. 2015, 41, 1432–1445.
10.1016/j.ultrasmedbio.2015.01.004
PubMed Web of Science® Google Scholar
8E. S. Basheva, P. A. Kralchevsky, N. C. Christov, K. D. Danov, S. D. Stoyanov, T. B. J. Blijdenstein, H.-J. Kim, E. G. Pelan, A. Lips, Langmuir 2011, 27, 2382–2392.
10.1021/la104726w
CAS PubMed Web of Science® Google Scholar
9A. R. Cox, F. Cagnol, A. B. Russell, M. J. Izzard, Langmuir 2007, 23, 7995–8002.
10.1021/la700451g
CAS PubMed Web of Science® Google Scholar
10M. A. Parrales, J. M. Fernandez, M. Perez-Saborid, J. A. Kopechek, T. M. Porter, J. Acoust. Soc. Am. 2014, 136, 1077–1084.
10.1121/1.4890643
PubMed Web of Science® Google Scholar
11
11aJ. G. Riess, Chem. Rev. 2001, 101, 2797–2920;
10.1021/cr970143c
CAS PubMed Web of Science® Google Scholar
11bS. F. Flaim, Artif. Cells Blood Substitutes Immobilization Biot 1994, 22, 1043–1054.
10.3109/10731199409138801
CAS PubMed Web of Science® Google Scholar
12
12aM. Sarparanta, L. M. Bimbo, J. Rytkönen, E. Mäkilä, T. J. Laaksonen, P. Laaksonen, M. Nyman, J. Salonen, M. B. Linder, J. Hirvonen, H. A. Santos, A. J. Airaksinen, Mol. Pharm. 2012, 9, 654–663;
10.1021/mp200611d
CAS PubMed Web of Science® Google Scholar
12bM. I. Janssen, M. B. M. van Leeuwen, K. Scholtmeijer, T. G. van Kooten, L. Dijkhuizen, H. A. B. Wösten, Biomaterials 2002, 23, 4847–4854;
10.1016/S0142-9612(02)00240-5
CAS PubMed Web of Science® Google Scholar
12cV. Aimanianda, J. Bayry, S. Bozza, O. Kniemeyer, K. Perruccio, S. R. Elluru, C. Clavaud, S. Paris, A. A. Brakhage, S. V. Kaveri, L. Romani, J.-P. Latge, Nature 2009, 460, 1117–1121;
10.1038/nature08264
CAS PubMed Web of Science® Google Scholar
12dQ. Ren, A. H. Kwan, M. Sunde, Pept. Sci. 2013, 100, 601–612.
10.1002/bip.22259
CAS PubMed Web of Science® Google Scholar
13F. Gerber, M. P. Krafft, T. F. Vandamme, M. Goldmann, P. Fontaine, Angew. Chem. Int. Ed. 2005, 44, 2749–2752;
10.1002/anie.200462978
CAS PubMed Web of Science® Google Scholar
Angew. Chem. 2005, 117, 2809–2812.
10.1002/ange.200462978
Web of Science® Google Scholar
14G. Yang, M. O′Duill, V. Gouverneur, M. P. Krafft, Angew. Chem. Int. Ed. 2015, 54, 8402–8406;
10.1002/anie.201502677
CAS PubMed Web of Science® Google Scholar
Angew. Chem. 2015, 127, 8522–8526.
10.1002/ange.201502677
Web of Science® Google Scholar
15M. Torkkeli, R. Serimaa, O. Ikkala, M. Linder, Biophys. J. 2002, 83, 2240–2247.
10.1016/S0006-3495(02)73984-2
CAS PubMed Web of Science® Google Scholar
16S. Rossi, G. Waton, M. P. Krafft, Langmuir 2010, 26, 1649–1655.
10.1021/la9025987
CAS PubMed Web of Science® Google Scholar

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Volume128, Issue35

August 22, 2016

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Design of Highly Stable Echogenic Microbubbles through Controlled Assembly of Their Hydrophobin Shell

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Design of Highly Stable Echogenic Microbubbles through Controlled Assembly of Their Hydrophobin Shell

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