Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine
Jenny Rackwitz
Institute of Chemistry—Physical Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24–25, 14476 Potsdam, Germany
Search for more papers by this authorDr. Janina Kopyra
Faculty of Sciences, Siedlce University, 3 Maja 54, 08-110 Siedlce, Poland
Search for more papers by this authorDr. Iwona Dąbkowska
Department of Chemistry, University of Gdańsk, 80-952 Gdańsk, Poland
Search for more papers by this authorKenny Ebel
Institute of Chemistry—Physical Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24–25, 14476 Potsdam, Germany
Search for more papers by this authorMiloŠ Lj. Ranković
Institute of Physics Belgrade, University of Belgrade, Pregrevica 118, 11080 Belgrade, Serbia
Search for more papers by this authorProf. Dr. Aleksandar R. Milosavljević
Institute of Physics Belgrade, University of Belgrade, Pregrevica 118, 11080 Belgrade, Serbia
SOLEIL, l'Orme des Merisiers, St. Aubin, BP48, 91192, Gif sur Yvette Cedex, France
Search for more papers by this authorCorresponding Author
Prof. Dr. Ilko Bald
Institute of Chemistry—Physical Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24–25, 14476 Potsdam, Germany
Department 1—Analytical Chemistry and Reference Materials, BAM Federal Institute for Materials Research and Testing, Richard-Willstätter Str. 11, 12489 Berlin, Germany
Search for more papers by this authorJenny Rackwitz
Institute of Chemistry—Physical Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24–25, 14476 Potsdam, Germany
Search for more papers by this authorDr. Janina Kopyra
Faculty of Sciences, Siedlce University, 3 Maja 54, 08-110 Siedlce, Poland
Search for more papers by this authorDr. Iwona Dąbkowska
Department of Chemistry, University of Gdańsk, 80-952 Gdańsk, Poland
Search for more papers by this authorKenny Ebel
Institute of Chemistry—Physical Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24–25, 14476 Potsdam, Germany
Search for more papers by this authorMiloŠ Lj. Ranković
Institute of Physics Belgrade, University of Belgrade, Pregrevica 118, 11080 Belgrade, Serbia
Search for more papers by this authorProf. Dr. Aleksandar R. Milosavljević
Institute of Physics Belgrade, University of Belgrade, Pregrevica 118, 11080 Belgrade, Serbia
SOLEIL, l'Orme des Merisiers, St. Aubin, BP48, 91192, Gif sur Yvette Cedex, France
Search for more papers by this authorCorresponding Author
Prof. Dr. Ilko Bald
Institute of Chemistry—Physical Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24–25, 14476 Potsdam, Germany
Department 1—Analytical Chemistry and Reference Materials, BAM Federal Institute for Materials Research and Testing, Richard-Willstätter Str. 11, 12489 Berlin, Germany
Search for more papers by this authorAbstract
2-Fluoroadenine (2FA) is a therapeutic agent, which is suggested for application in cancer radiotherapy. The molecular mechanism of DNA radiation damage can be ascribed to a significant extent to the action of low-energy (<20 eV) electrons (LEEs), which damage DNA by dissociative electron attachment. LEE induced reactions in 2FA are characterized both isolated in the gas phase and in the condensed phase when it is incorporated into DNA. Information about negative ion resonances and anion-mediated fragmentation reactions is combined with an absolute quantification of DNA strand breaks in 2FA-containing oligonucleotides upon irradiation with LEEs. The incorporation of 2FA into DNA results in an enhanced strand breakage. The strand-break cross sections are clearly energy dependent, whereas the strand-break enhancements by 2FA at 5.5, 10, and 15 eV are very similar. Thus, 2FA can be considered an effective radiosensitizer operative at a wide range of electron energies.
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