Enantioconvergent Fukuyama Cross-Coupling of Racemic Benzylic Organozinc Reagents
Rik Oost
University of Vienna, Faculty of Chemistry, Institute of Organic Chemistry, Währinger Strasse 38, 1090 Vienna, Austria
Search for more papers by this authorDr. Antonio Misale
University of Vienna, Faculty of Chemistry, Institute of Organic Chemistry, Währinger Strasse 38, 1090 Vienna, Austria
Search for more papers by this authorCorresponding Author
Prof. Dr. Nuno Maulide
University of Vienna, Faculty of Chemistry, Institute of Organic Chemistry, Währinger Strasse 38, 1090 Vienna, Austria
Search for more papers by this authorRik Oost
University of Vienna, Faculty of Chemistry, Institute of Organic Chemistry, Währinger Strasse 38, 1090 Vienna, Austria
Search for more papers by this authorDr. Antonio Misale
University of Vienna, Faculty of Chemistry, Institute of Organic Chemistry, Währinger Strasse 38, 1090 Vienna, Austria
Search for more papers by this authorCorresponding Author
Prof. Dr. Nuno Maulide
University of Vienna, Faculty of Chemistry, Institute of Organic Chemistry, Währinger Strasse 38, 1090 Vienna, Austria
Search for more papers by this authorAbstract
The first enantioconvergent palladium-catalyzed Fukuyama cross-coupling of racemic benzylic organozinc reagents with thioesters has been developed. The reaction furnishes enantioenriched acyclic α-disubstituted ketone products in good yields and high enantioselectivities. A broad substrate scope is achieved under mild reaction conditions to prevent racemization of the potentially labile tertiary stereocenters.
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