Peptide [4]Catenane by Folding and Assembly
Corresponding Author
Dr. Tomohisa Sawada
Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan
Search for more papers by this authorMotoya Yamagami
Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan
Search for more papers by this authorDr. Kazuaki Ohara
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa, 769-2193 Japan
Search for more papers by this authorProf. Dr. Kentaro Yamaguchi
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa, 769-2193 Japan
Search for more papers by this authorCorresponding Author
Prof. Dr. Makoto Fujita
Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan
Search for more papers by this authorCorresponding Author
Dr. Tomohisa Sawada
Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan
Search for more papers by this authorMotoya Yamagami
Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan
Search for more papers by this authorDr. Kazuaki Ohara
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa, 769-2193 Japan
Search for more papers by this authorProf. Dr. Kentaro Yamaguchi
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa, 769-2193 Japan
Search for more papers by this authorCorresponding Author
Prof. Dr. Makoto Fujita
Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan
Search for more papers by this authorAbstract
A topologically complex peptide [4]catenane with the crossing number of 12 was synthesized by a folding and assembly strategy wherein the folding and metal-directed self-assembly of a short peptide fragment occur simultaneously. The latent Ω-looped conformation of the Pro-Gly-Pro sequence was found only when pyridines at the C- and N-termini coordinatively bind metal ions (AgI or AuI). Crystallographic studies revealed that the Ω-looped motifs formed four M3L3 macrocycles that were intermolecularly entwined to generate an unprecedented peptide [4]catenane topology.
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