Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins
Dr. Xi Zhu
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
These authors contributed equally to this work.
Search for more papers by this authorDr. Jun Wu
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
These authors contributed equally to this work.
Search for more papers by this authorWei Shan
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorDr. Wei Tao
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
Search for more papers by this authorDr. Lili Zhao
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
Search for more papers by this authorDr. Jong-Min Lim
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA
Search for more papers by this authorMathew D'Ortenzio
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
Search for more papers by this authorProf. Rohit Karnik
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA
Search for more papers by this authorCorresponding Author
Prof. Yuan Huang
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorCorresponding Author
Prof. Jinjun Shi
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
Search for more papers by this authorCorresponding Author
Prof. Omid C. Farokhzad
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
King Abdulaziz University, Jeddah, Saudi Arabia
Search for more papers by this authorDr. Xi Zhu
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
These authors contributed equally to this work.
Search for more papers by this authorDr. Jun Wu
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
These authors contributed equally to this work.
Search for more papers by this authorWei Shan
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorDr. Wei Tao
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
Search for more papers by this authorDr. Lili Zhao
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
Search for more papers by this authorDr. Jong-Min Lim
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA
Search for more papers by this authorMathew D'Ortenzio
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
Search for more papers by this authorProf. Rohit Karnik
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA
Search for more papers by this authorCorresponding Author
Prof. Yuan Huang
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorCorresponding Author
Prof. Jinjun Shi
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
Search for more papers by this authorCorresponding Author
Prof. Omid C. Farokhzad
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA
King Abdulaziz University, Jeddah, Saudi Arabia
Search for more papers by this authorAbstract
Effective delivery of therapeutic proteins is a formidable challenge. Herein, using a unique polymer family with a wide-ranging set of cationic and hydrophobic features, we developed a novel nanoparticle (NP) platform capable of installing protein ligands on the particle surface and simultaneously carrying therapeutic proteins inside by a self-assembly procedure. The loaded therapeutic proteins (e.g., insulin) within the NPs exhibited sustained and tunable release, while the surface-coated protein ligands (e.g., transferrin) were demonstrated to alter the NP cellular behaviors. In vivo results revealed that the transferrin-coated NPs can effectively be transported across the intestinal epithelium for oral insulin delivery, leading to a notable hypoglycemic response.
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