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Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids

Olivia Schimming

Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt am Main (Germany) http://www.bio.uni-frankfurt.de/48050101

These authors contributed equally to this work.

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Dr. Victoria L. Challinor,

Dr. Victoria L. Challinor

These authors contributed equally to this work.

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Dr. Nicholas J. Tobias,

Dr. Nicholas J. Tobias

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Dr. Hélène Adihou,

Dr. Hélène Adihou

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Peter Grün,

Peter Grün

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Laura Pöschel,

Laura Pöschel

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Dr. Christian Richter,

Dr. Christian Richter

Institut für Organische und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz, Goethe Universität Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany)

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Prof. Dr. Harald Schwalbe,

Prof. Dr. Harald Schwalbe

Institut für Organische und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz, Goethe Universität Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany)

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Prof. Dr. Helge B. Bode,

Corresponding Author

Prof. Dr. Helge B. Bode

[email protected]

Buchmann Institute for Molecular Life Sciences (BMLS), Goethe Universität Frankfurt, Max-von-Laue-Strasse 15, 60438 Frankfurt am Main (Germany)

Olivia Schimming,

Olivia Schimming

These authors contributed equally to this work.

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Dr. Victoria L. Challinor,

Dr. Victoria L. Challinor

These authors contributed equally to this work.

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Dr. Nicholas J. Tobias,

Dr. Nicholas J. Tobias

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Dr. Hélène Adihou,

Dr. Hélène Adihou

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Peter Grün,

Peter Grün

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Laura Pöschel,

Laura Pöschel

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Dr. Christian Richter,

Dr. Christian Richter

Institut für Organische und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz, Goethe Universität Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany)

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Prof. Dr. Harald Schwalbe,

Prof. Dr. Harald Schwalbe

Institut für Organische und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz, Goethe Universität Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany)

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Prof. Dr. Helge B. Bode,

Corresponding Author

Prof. Dr. Helge B. Bode

[email protected]

Buchmann Institute for Molecular Life Sciences (BMLS), Goethe Universität Frankfurt, Max-von-Laue-Strasse 15, 60438 Frankfurt am Main (Germany)

First published: 25 August 2015

https://doi.org/10.1002/ange.201504877

Citations: 10

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Abstract

Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non-ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram-negative and Gram-positive bacteria indicates an important biological function in bacteria.

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Volume127, Issue43

October 19, 2015

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Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids

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Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids

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