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The Nucleoside Uridine Isolated in the Gas Phase^†

Dr. Isabel Peña

Grupo de Espectroscopía Molecular (GEM), Edificio Quifima, Laboratorio de Espectroscopia y Bioespectroscopia, Unidad Asociada CSIC, Parque Científico Uva, Universidad de Valladolid, 47011 Valladolid (Spain) http://www.gem.uva.es

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Dr. Carlos Cabezas,

Dr. Carlos Cabezas

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Prof. José L. Alonso,

Corresponding Author

Prof. José L. Alonso

[email protected]

Dr. Isabel Peña,

Dr. Isabel Peña

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Dr. Carlos Cabezas,

Dr. Carlos Cabezas

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Prof. José L. Alonso,

Corresponding Author

Prof. José L. Alonso

[email protected]

First published: 12 February 2015

https://doi.org/10.1002/ange.201412460

Citations: 8

^†

This research was supported by Ministerio de Ciencia e Innovación (grant numbers CTQ 2010-19008, CTQ 2013-40717-P and Consolider Ingenio 2010 CSD 2009-00038), Junta de Castilla y León (grant number VA175U13) and ERC (grant number 610256 “Nanocosmos”). C.C. thanks the Junta de Castilla y León for the postdoctoral contract (grant number CIP13/01).

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Abstract

Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform (FT) microwave techniques. Free from the bulk effects of their native environments, anti/C2′-endo-g+ conformation has been revealed as the most stable form of uridine. Intramolecular hydrogen bonds involving uracil and ribose moieties have been found to play an important role in the stabilization of the nucleoside.

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Volume127, Issue10

March 2, 2015

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The Nucleoside Uridine Isolated in the Gas Phase^†

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The Nucleoside Uridine Isolated in the Gas Phase^†