Chirality-Assisted Ring-Like Aggregation of Aβ(1–40) at Liquid–Solid Interfaces: A Stereoselective Two-Step Assembly Process†
Guanbin Gao
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070 (PR China)
These authors contributed equally to this work.
Search for more papers by this authorProf. Mingxi Zhang
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070 (PR China)
These authors contributed equally to this work.
Search for more papers by this authorDr. Pei Lu
Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (PR China)
Search for more papers by this authorDr. Guanlun Guo
Hubei Key Laboratory of Advanced Technology of Automotive Components, Wuhan University of Technology, Wuhan 430070 (PR China)
Search for more papers by this authorProf. Dong Wang
Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (PR China)
Search for more papers by this authorCorresponding Author
Prof. Taolei Sun
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070 (PR China)
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070 (PR China)
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070 (PR China)Search for more papers by this authorGuanbin Gao
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070 (PR China)
These authors contributed equally to this work.
Search for more papers by this authorProf. Mingxi Zhang
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070 (PR China)
These authors contributed equally to this work.
Search for more papers by this authorDr. Pei Lu
Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (PR China)
Search for more papers by this authorDr. Guanlun Guo
Hubei Key Laboratory of Advanced Technology of Automotive Components, Wuhan University of Technology, Wuhan 430070 (PR China)
Search for more papers by this authorProf. Dong Wang
Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (PR China)
Search for more papers by this authorCorresponding Author
Prof. Taolei Sun
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070 (PR China)
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070 (PR China)
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070 (PR China)Search for more papers by this authorThis work was supported by National Natural Science Foundation of China (91127027, 51173142, 21105078), the China National Funds for Distinguished Young Scientists (51325302), the Major State Basic Research Development Program of China (973 Program: 2013CB933002), the Program for Changjiang Scholars and Innovative Research Team in University (IRT1169), and the Program of Introducing Talents of Discipline to Universities (B13035).
Abstract
Molecular chirality is introduced at liquid–solid interfaces. A ring-like aggregation of amyloid Aβ(1–40) on N-isobutyryl-L-cysteine (L-NIBC)-modified gold substrate occurs at low Aβ(1–40) concentration, while D-NIBC modification only results in rod-like aggregation. Utilizing atomic force microscope controlled tip-enhanced Raman scattering, we directly observe the secondary structure information for Aβ(1–40) assembly in situ at the nanoscale. D- or L-NIBC on the surface can guide parallel or nonparallel alignment of β-hairpins through a two-step process based on electrostatic-interaction-enhanced adsorption and subsequent stereoselective recognition. Possible electrostatic interaction sites (R5 and K16) and a chiral recognition site (H14) of Aβ(1–40) are proposed, which may provide insight into the understanding of this effect.
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