Self-Assembly of a Giant Molecular Solomon Link from 30 Subcomponents†
Dr. Clément Schouwey
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Search for more papers by this authorDr. Julian J. Holstein
Global Phasing Ltd., Sheraton House, Castle Park, Cambridge CB3 0AX (UK)
Current address: GZG, Abteilung Kristallographie, Georg-August-Universität Göttingen, Goldschmidtstr. 1, 37077 Göttingen (Germany)
Search for more papers by this authorDr. Rosario Scopelliti
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Search for more papers by this authorKonstantin O. Zhurov
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Search for more papers by this authorDr. Konstantin O. Nagornov
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Search for more papers by this authorProf. Yury O. Tsybin
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Search for more papers by this authorDr. Oliver S. Smart
Global Phasing Ltd., Sheraton House, Castle Park, Cambridge CB3 0AX (UK)
Search for more papers by this authorDr. Gérard Bricogne
Global Phasing Ltd., Sheraton House, Castle Park, Cambridge CB3 0AX (UK)
Search for more papers by this authorCorresponding Author
Prof. Kay Severin
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)Search for more papers by this authorDr. Clément Schouwey
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Search for more papers by this authorDr. Julian J. Holstein
Global Phasing Ltd., Sheraton House, Castle Park, Cambridge CB3 0AX (UK)
Current address: GZG, Abteilung Kristallographie, Georg-August-Universität Göttingen, Goldschmidtstr. 1, 37077 Göttingen (Germany)
Search for more papers by this authorDr. Rosario Scopelliti
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Search for more papers by this authorKonstantin O. Zhurov
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Search for more papers by this authorDr. Konstantin O. Nagornov
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Search for more papers by this authorProf. Yury O. Tsybin
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Search for more papers by this authorDr. Oliver S. Smart
Global Phasing Ltd., Sheraton House, Castle Park, Cambridge CB3 0AX (UK)
Search for more papers by this authorDr. Gérard Bricogne
Global Phasing Ltd., Sheraton House, Castle Park, Cambridge CB3 0AX (UK)
Search for more papers by this authorCorresponding Author
Prof. Kay Severin
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)Search for more papers by this authorThis work was supported by funding from the Swiss National Science Foundation, a Marie Curie fellowship for J.J.H. (ITN-2010-264645), and by the EPFL. We thank Dr. Pascal Miéville for his help with DOSY experiments, and Prof. Dr. Anthony L. Spek for providing updated CHECKCIF routines to handle structures of the Solomon link’s size.
Abstract
The synthesis of topologically complex structures, such as links and knots, is one of the current challenges in supramolecular chemistry. The so-called Solomon link consists of two doubly interlocked rings. Despite being a rather simple link from a topological point of view, only few molecular versions of this link have been described so far. Here, we report the quantitative synthesis of a giant molecular Solomon link from 30 subcomponents. The highly charged structure is formed by assembly of 12 cis-blocked Pt2+ complexes, six Cu+ ions, and 12 rigid N-donor ligands. Each of the two interlocked rings is composed of six repeating Pt(ligand) units, while the six Cu+ ions connect the two rings. With a molecular weight of nearly 12 kDa and a diameter of 44.2 Å, this complex is the largest non-DNA-based Solomon link described so far. Furthermore, it represents a molecular version of a “stick link”.
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