Reversibly Controlling Preferential Protein Adsorption on Bone Implants by Using an Applied Weak Potential as a Switch†
Jingwen Liao
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
These authors contributed equally to this work.
Search for more papers by this authorYe Zhu
Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma (USA)
These authors contributed equally to this work.
Search for more papers by this authorZhengnan Zhou
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Search for more papers by this authorJunqi Chen
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Search for more papers by this authorCorresponding Author
Guoxin Tan
Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006 (China)
Guoxin Tan, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006 (China)
Chengyun Ning, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Chuanbin Mao, Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma (USA)
Search for more papers by this authorCorresponding Author
Prof. Chengyun Ning
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Guoxin Tan, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006 (China)
Chengyun Ning, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Chuanbin Mao, Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma (USA)
Search for more papers by this authorCorresponding Author
Prof. Chuanbin Mao
Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma (USA)
Guoxin Tan, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006 (China)
Chengyun Ning, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Chuanbin Mao, Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma (USA)
Search for more papers by this authorJingwen Liao
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
These authors contributed equally to this work.
Search for more papers by this authorYe Zhu
Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma (USA)
These authors contributed equally to this work.
Search for more papers by this authorZhengnan Zhou
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Search for more papers by this authorJunqi Chen
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Search for more papers by this authorCorresponding Author
Guoxin Tan
Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006 (China)
Guoxin Tan, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006 (China)
Chengyun Ning, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Chuanbin Mao, Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma (USA)
Search for more papers by this authorCorresponding Author
Prof. Chengyun Ning
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Guoxin Tan, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006 (China)
Chengyun Ning, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Chuanbin Mao, Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma (USA)
Search for more papers by this authorCorresponding Author
Prof. Chuanbin Mao
Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma (USA)
Guoxin Tan, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006 (China)
Chengyun Ning, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China)
Chuanbin Mao, Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma (USA)
Search for more papers by this authorThis work was supported by the National Basic Research Program of China (Grant No. 2012CB619100) and the National Natural Science Foundation of China (Grant Nos. 51372087, 51072057). Y.Z. and C.M. would like to thank the financial support from National Institutes of Health (EB015190), National Science Foundation (CBET-0854414, CMMI-1234957, and DMR-0847758), Department of Defense Peer Reviewed Medical Research Program (W81XWH-12-1-0384), Oklahoma Center for Adult Stem Cell Research (434003), and Oklahoma Center for the Advancement of Science and Technology (HR14-160). We would like to thank Xuliang Deng’s group at Peking University for their assistance during the experiments.
Abstract
A facile method is needed to control the protein adsorption onto biomaterials, such as, bone implants. Herein we doped taurocholic acid (TCA), an amphiphilic biomolecule, into an array of 1D nano-architectured polypyrrole (NAPPy) on the implants. Doping TCA enabled the implant surface to show reversible wettability between 152° (superhydrophobic, switch-on state) and 55° (hydrophilic, switch-off state) in response to periodically switching two weak electrical potentials (+0.50 and −0.80 V as a switch-on and switch-off potential, respectively). The potential-switchable reversible wettability, arising from the potential-tunable orientation of the hydrophobic and hydrophilic face of TCA, led to potential-switchable preferential adsorption of proteins as well as cell adhesion and spreading. This potential-switchable strategy may open up a new avenue to control the biological activities on the implant surface.
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