Aldehyde-Assisted Ruthenium(II)-Catalyzed CH Oxygenations†
M. Sc. Fanzhi Yang
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
Search for more papers by this authorKarsten Rauch
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
Search for more papers by this authorM. Sc. Katharina Kettelhoit
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
Search for more papers by this authorCorresponding Author
Prof. Dr. Lutz Ackermann
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/Search for more papers by this authorM. Sc. Fanzhi Yang
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
Search for more papers by this authorKarsten Rauch
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
Search for more papers by this authorM. Sc. Katharina Kettelhoit
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
Search for more papers by this authorCorresponding Author
Prof. Dr. Lutz Ackermann
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/Search for more papers by this authorGenerous support by the European Research Council under the European Community’s Seventh Framework Program (FP7 2007–2013; ERC Grant 307535), the CaSuS program, and the Chinese Scholarship Program (fellowship to F.Y.) is gratefully acknowledged.
Abstract
Versatile ruthenium(II) complexes allow for site-selective CH oxygenations with weakly-coordinating aldehydes. The challenging CH functionalizations proceed with high chemoselectivity by rate-determining CH metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.
Supporting Information
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