Volume 125, Issue 44 pp. 11723-11726
Zuschrift

Organocatalytic Asymmetric Synthesis of Propargylamines with Two Adjacent Stereocenters: Mannich-Type Reactions of In Situ Generated C-Alkynyl Imines with β-Keto Esters

Dr. Taichi Kano

Dr. Taichi Kano

Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502 (Japan)

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Dr. Taiga Yurino

Dr. Taiga Yurino

Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502 (Japan)

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Prof. Keiji Maruoka

Corresponding Author

Prof. Keiji Maruoka

Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502 (Japan)

Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502 (Japan)Search for more papers by this author
First published: 05 September 2013
Citations: 15

This work was supported by a Grant-in-Aid for Scientific Research from MEXT (Japan). T.Y. thanks the Japan Society for the Promotion of Science for Young Scientists for Research Fellowships.

Graphical Abstract

Seite an Seite: Die Titelreaktion wird durch eine chirale Brønsted-Säure (S)-1 katalysiert und ergibt bisher schwer zugängliche chirale Propargylamine mit zwei benachbarten Stereozentren mit guten bis exzellenten Diastereo- und Enantioselektivitäten. Boc=tert-Butoxycarbonyl.

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