Synthesis of Single-Chain Sugar Arrays†
Nathalie Baradel
Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)
Search for more papers by this authorDr. Sébastien Fort
Oligosaccharides Chemistry and Biotechnology, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), BP 53, 38041 Grenoble Cedex 9 (France)
Search for more papers by this authorDr. Sami Halila
Oligosaccharides Chemistry and Biotechnology, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), BP 53, 38041 Grenoble Cedex 9 (France)
Search for more papers by this authorDr. Nezha Badi
Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)
Search for more papers by this authorCorresponding Author
Dr. Jean-François Lutz
Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)
Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)===Search for more papers by this authorNathalie Baradel
Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)
Search for more papers by this authorDr. Sébastien Fort
Oligosaccharides Chemistry and Biotechnology, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), BP 53, 38041 Grenoble Cedex 9 (France)
Search for more papers by this authorDr. Sami Halila
Oligosaccharides Chemistry and Biotechnology, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), BP 53, 38041 Grenoble Cedex 9 (France)
Search for more papers by this authorDr. Nezha Badi
Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)
Search for more papers by this authorCorresponding Author
Dr. Jean-François Lutz
Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)
Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)===Search for more papers by this authorThe research leading to these results was partially funded by the European Research Council under the Seventh Framework Program of the European Union (FP7/2007-2013) and the ERC grant agreement No. 258593. The CNRS, the University of Strasbourg, and the icFRC are also acknowledged for financial support. We thank M. Legros, O. Gavat, and C. Foussat for the SEC measurements. P. Chaud and S. Pradeau are also acknowledged for their help in the preparation of azido sugars.
Graphical Abstract
Hexosen in Reih und Glied: Wohldefinierte lineare Polystyrolketten mit präzise positionierten Hexosegruppen (Mannose, Galactose und N-Acetylglucosamin) wurden durch sequenzkontrollierte Polymerisation synthetisiert und in ortsselektiven Modifizierungsschritten weiter umgesetzt. Die multifunktionellen Hexose-Reihen assoziieren mit komplementären Lectinen (siehe Bild).
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