Stoichiometric Leverage: Rapid 18F-Aryltrifluoroborate Radiosynthesis at High Specific Activity for Click Conjugation†
Zhibo Liu
Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T-1Z1 (Canada)
Search for more papers by this authorDr. Ying Li
Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T-1Z1 (Canada)
Search for more papers by this authorJerome Lozada
Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T-1Z1 (Canada)
Search for more papers by this authorDr. Paul Schaffer
Triumf, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3 (Canada)
Search for more papers by this authorDr. Michael J. Adam
Triumf, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3 (Canada)
Search for more papers by this authorDr. Thomas J. Ruth
Triumf, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3 (Canada)
Search for more papers by this authorCorresponding Author
Dr. David M. Perrin
Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T-1Z1 (Canada)
Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T-1Z1 (Canada)===Search for more papers by this authorZhibo Liu
Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T-1Z1 (Canada)
Search for more papers by this authorDr. Ying Li
Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T-1Z1 (Canada)
Search for more papers by this authorJerome Lozada
Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T-1Z1 (Canada)
Search for more papers by this authorDr. Paul Schaffer
Triumf, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3 (Canada)
Search for more papers by this authorDr. Michael J. Adam
Triumf, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3 (Canada)
Search for more papers by this authorDr. Thomas J. Ruth
Triumf, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3 (Canada)
Search for more papers by this authorCorresponding Author
Dr. David M. Perrin
Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T-1Z1 (Canada)
Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T-1Z1 (Canada)===Search for more papers by this authorThis work was supported by grants from the Canadian Cancer Society (20071), NSERC, and the CIHR. We thank Drs. Hua Yang and Qing Miao for labeling assistance.
Graphical Abstract
Rund zehn Mal höhere spezifische Aktivität: Die meisten 18F-markierten Radiotracer haben eine spezifische Aktivität unter 2 Ci μmol−1, während mit 18F-Aryltrifluoroboraten Werte bis 15 Ci μmol−1 möglich sind. Dies wurde durch das Anknüpfen eines [18F]-ArBF3−-Anions an Rhodamin mithilfe der Klickchemie bestätigt, was eine rasche und verallgemeinerbare Eintopfmethode zur Erzeugung fluoreszierender Tracer belegt.
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