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Monitoring of Protein Arginine Deiminase Activity by Using Fluorescence Quenching: Multicolor Visualization of Citrullination^†

Prof. Qunzhao Wang

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)

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Prof. Melanie A. Priestman,

Prof. Melanie A. Priestman

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)

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Prof. David S. Lawrence,

Corresponding Author

Prof. David S. Lawrence

[email protected]

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)===Search for more papers by this author

Prof. Qunzhao Wang,

Prof. Qunzhao Wang

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)

Search for more papers by this author

Prof. Melanie A. Priestman,

Prof. Melanie A. Priestman

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)

Search for more papers by this author

Prof. David S. Lawrence,

Corresponding Author

Prof. David S. Lawrence

[email protected]

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA)

First published: 21 January 2013

https://doi.org/10.1002/ange.201208464

Citations: 2

^†

We thank the NIH (CA159189) for financial support.

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Graphical Abstract

Farbig: Die Protein-Arginin-Desiminasen gehören zu einer Enzymfamilie, die posttranslationale Histonmodifikationen und die folgenden Änderungen der Genexpression katalysiert. Ein Verfahren, das zu Änderungen der Fluoreszenz im sichtbaren Spektrum führt, ermöglicht die visuelle Detektion der katalytischen Aktivität. Die Verwendung verschiedener Fluorophore (siehe Bild) erlaubt die simultane Vielfarben-Verfolgung einer Mischung Histon-modifizierender Enzyme.

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Volume125, Issue8

February 18, 2013

Pages 2379-2381

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Monitoring of Protein Arginine Deiminase Activity by Using Fluorescence Quenching: Multicolor Visualization of Citrullination^†

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Monitoring of Protein Arginine Deiminase Activity by Using Fluorescence Quenching: Multicolor Visualization of Citrullination†

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Monitoring of Protein Arginine Deiminase Activity by Using Fluorescence Quenching: Multicolor Visualization of Citrullination^†