Elucidating the Biosynthetic Pathway for Vibralactone: A Pancreatic Lipase Inhibitor with a Fused Bicyclic β-Lactone†
Correction(s) for this article
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Berichtigung: Elucidating the Biosynthetic Pathway for Vibralactone: A Pancreatic Lipase Inhibitor with a Fused Bicyclic β-Lactone
- Volume 125Issue 20Angewandte Chemie
- pages: 5311-5311
- First Published online: May 3, 2013
Corresponding Author
Dr. Pei-Ji Zhao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/===Search for more papers by this authorYan-Long Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/
University of Chinese Academy of Sciences, Beijing 100049 (China)
Search for more papers by this authorProf. Dr. Liangchen Du
Department of Chemistry, University of Nebraska-Lincoln, Lincoln NE 68588-0304 (USA)
Search for more papers by this authorProf. Dr. Ji-Kai Liu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/
Search for more papers by this authorCorresponding Author
Prof. Ying Zeng
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/===Search for more papers by this authorCorresponding Author
Dr. Pei-Ji Zhao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/===Search for more papers by this authorYan-Long Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/
University of Chinese Academy of Sciences, Beijing 100049 (China)
Search for more papers by this authorProf. Dr. Liangchen Du
Department of Chemistry, University of Nebraska-Lincoln, Lincoln NE 68588-0304 (USA)
Search for more papers by this authorProf. Dr. Ji-Kai Liu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/
Search for more papers by this authorCorresponding Author
Prof. Ying Zeng
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (China) http://english.kib.cas.cn/OurTearms/===Search for more papers by this authorThis research was supported by grants from the National Natural Science Foundation of China (31170061), and the National Basic Research Program of China (973 program, 2009CB522300 and 2013CB127500). We are grateful to Wolfgang Eisenreich (Technical University of Munich (Germany)), Zi-Hua Justin Jiang (Lakehead University, Canada) and anonymous reviewers for their comments.
Graphical Abstract
Nicht so einfach: Laut 13C-Markierungsstudien, Metabolit-Profiling und zellfreien Reaktionen tragen sowohl der Shikimat- als auch der Phenylalanin-Biosyntheseweg zum Aufbau der bicyclischen Struktur des Vibralactons bei. Das Enzym VibPT sowie eine aromatische PTase, die erstmals in Basidiomyceten charakterisiert wurde, sind an der Vibralacton-Biosynthese beteiligt. OPP=Pyrophosphat.
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