Evidence for the Natural Toxins from the Mushroom Trogia venenata as a Cause of Sudden Unexpected Death in Yunnan Province, China†
Dr. Zhong-Yu Zhou
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650 (China)
These authors contributed equally to this work.
Search for more papers by this authorDr. Guo-Qing Shi
Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
These authors contributed equally to this work.
Search for more papers by this authorDr. Robert Fontaine
Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
United States Centers for Disease Control and Prevention, Atlanta, GA 30333 (USA)
Search for more papers by this authorKun Wei
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorTao Feng
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorFang Wang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorGang-Qiang Wang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorYan Qu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorZheng-Hui Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorZe-Jun Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorHua-Jie Zhu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorZhu-Liang Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorCorresponding Author
Prof. Guang Zeng
Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
Guang Zeng, Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
Ji-Kai Liu, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Ji-Kai Liu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Guang Zeng, Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
Ji-Kai Liu, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorDr. Zhong-Yu Zhou
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650 (China)
These authors contributed equally to this work.
Search for more papers by this authorDr. Guo-Qing Shi
Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
These authors contributed equally to this work.
Search for more papers by this authorDr. Robert Fontaine
Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
United States Centers for Disease Control and Prevention, Atlanta, GA 30333 (USA)
Search for more papers by this authorKun Wei
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorTao Feng
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorFang Wang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorGang-Qiang Wang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorYan Qu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorZheng-Hui Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorZe-Jun Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorHua-Jie Zhu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorZhu-Liang Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorCorresponding Author
Prof. Guang Zeng
Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
Guang Zeng, Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
Ji-Kai Liu, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Ji-Kai Liu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Guang Zeng, Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
Ji-Kai Liu, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
Search for more papers by this authorThis project was supported by the National Basic Research Program of China (973 Program, 2009CB522300), the National Natural Sciences Foundation of China (30830113, U1132607), and Scientific Research Special Funds from the Ministry of Health (200802002). We thank Dr. R. Stone for reading our manuscript and for helpful suggestions.
Graphical Abstract
Überlebenswichtige Informationen: Die beiden ungewöhnlichen Aminosäuren 2R-Amino-4S-hydroxy-5-hexinsäure (rot) und 2R-Amino-5-hexinsäure (blau) wurden aus Fruchtkörpern des Pilzes Trogia venenata isoliert. Toxikologische Studien bringen diese beiden giftigen Substanzen mit plötzlichen Todesfällen („Sudden Unexplained Death“) in der chinesischen Provinz Yunnan in Verbindung.
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