Conjugate Addition/Cyclization Sequence Enables Selective and Simultaneous Fluorescence Detection of Cysteine and Homocysteine†
Corresponding Author
Dr. Xiaofeng Yang
Department of Chemistry, Portland State University, 1719 SW 10 Ave, Portland, OR 97201 (USA) http://www.pdx.edu/chem/profile/dr-robert-strongin
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Institute of Analytical Sciences, College of Chemistry & Materials Science, Northwest University, Xi'an 710069 (P.R. China)
Department of Chemistry, Portland State University, 1719 SW 10 Ave, Portland, OR 97201 (USA) http://www.pdx.edu/chem/profile/dr-robert-stronginSearch for more papers by this authorYixing Guo
Department of Chemistry, Portland State University, 1719 SW 10 Ave, Portland, OR 97201 (USA) http://www.pdx.edu/chem/profile/dr-robert-strongin
Search for more papers by this authorCorresponding Author
Prof. Robert M. Strongin
Department of Chemistry, Portland State University, 1719 SW 10 Ave, Portland, OR 97201 (USA) http://www.pdx.edu/chem/profile/dr-robert-strongin
Department of Chemistry, Portland State University, 1719 SW 10 Ave, Portland, OR 97201 (USA) http://www.pdx.edu/chem/profile/dr-robert-stronginSearch for more papers by this authorCorresponding Author
Dr. Xiaofeng Yang
Department of Chemistry, Portland State University, 1719 SW 10 Ave, Portland, OR 97201 (USA) http://www.pdx.edu/chem/profile/dr-robert-strongin
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Institute of Analytical Sciences, College of Chemistry & Materials Science, Northwest University, Xi'an 710069 (P.R. China)
Department of Chemistry, Portland State University, 1719 SW 10 Ave, Portland, OR 97201 (USA) http://www.pdx.edu/chem/profile/dr-robert-stronginSearch for more papers by this authorYixing Guo
Department of Chemistry, Portland State University, 1719 SW 10 Ave, Portland, OR 97201 (USA) http://www.pdx.edu/chem/profile/dr-robert-strongin
Search for more papers by this authorCorresponding Author
Prof. Robert M. Strongin
Department of Chemistry, Portland State University, 1719 SW 10 Ave, Portland, OR 97201 (USA) http://www.pdx.edu/chem/profile/dr-robert-strongin
Department of Chemistry, Portland State University, 1719 SW 10 Ave, Portland, OR 97201 (USA) http://www.pdx.edu/chem/profile/dr-robert-stronginSearch for more papers by this authorSupport from the National Institutes of Health through award RO1 EB002044 is gratefully acknowledged. X.F.Y. acknowledges financial support from the China Scholarship Council.
Graphical Abstract
Ähnlich, doch nicht gleich: Ein Benzothiazolderivat kann Cystein (Cys) und Homocystein (Hcy) parallel in neutralen Medien nachweisen. Bei dieser Methode wird zunächst ein Thioether gebildet, bevor eine Lactamcyclisierung unter Freisetzung von 2-(2′-Hydroxy-3′-methoxyphenyl)benzothiazol (HMBT) erfolgt. Der unterschiedlich schnelle Ringschluss ermöglicht die Identifizierung von Cys und Hcy auf spektralem oder kinetischem Weg.
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