Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding†
Dr. Aline Dantas de Araujo
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/
Search for more papers by this authorDr. Brid Callaghan
Health Innovations Research Institute, RMIT University, Melbourne, VIC 3083 (Australia)
Search for more papers by this authorDr. Simon T. Nevin
Queensland Brain Institute, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorDr. Norelle L. Daly
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/
Search for more papers by this authorProf. David J. Craik
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/
Search for more papers by this authorMelissa Moretta
Brain and Mind Research, The University of Sydney, NSW 2006 (Australia)
Search for more papers by this authorDr. Gene Hopping
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/
Search for more papers by this authorProf. Macdonald J. Christie
Brain and Mind Research, The University of Sydney, NSW 2006 (Australia)
Search for more papers by this authorProf. David J. Adams
Health Innovations Research Institute, RMIT University, Melbourne, VIC 3083 (Australia)
Search for more papers by this authorCorresponding Author
Prof. Paul F. Alewood
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/Search for more papers by this authorDr. Aline Dantas de Araujo
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/
Search for more papers by this authorDr. Brid Callaghan
Health Innovations Research Institute, RMIT University, Melbourne, VIC 3083 (Australia)
Search for more papers by this authorDr. Simon T. Nevin
Queensland Brain Institute, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorDr. Norelle L. Daly
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/
Search for more papers by this authorProf. David J. Craik
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/
Search for more papers by this authorMelissa Moretta
Brain and Mind Research, The University of Sydney, NSW 2006 (Australia)
Search for more papers by this authorDr. Gene Hopping
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/
Search for more papers by this authorProf. Macdonald J. Christie
Brain and Mind Research, The University of Sydney, NSW 2006 (Australia)
Search for more papers by this authorProf. David J. Adams
Health Innovations Research Institute, RMIT University, Melbourne, VIC 3083 (Australia)
Search for more papers by this authorCorresponding Author
Prof. Paul F. Alewood
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia), Fax: (+61) 7-33462101 http://uq.edu.au/alewood/Search for more papers by this authorWe thank the NHRMC for financial support.
Graphical Abstract
Eine Lösung für Faltungsprobleme: Selenocystein(Sec)-Reste wurden genutzt, um die Faltung von Conotoxin MrVIB, einem vormals „unfaltbaren“ Miniprotein mit therapeutischem Potenzial, zu induzieren (siehe Bild). Diese Strategie für die einfache Faltung von Peptiden und Proteinen mit mehreren Disulfidbindungen dürfte allgemein anwendbar sein.
Supporting Information
Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors.
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