Constructing Multiply Substituted Arenes Using Sequential Palladium(II)-Catalyzed CH Olefination†
Keary M. Engle
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-2409 http://www.scripps.edu/chem/yu/index/html
Search for more papers by this authorDong-Hui Wang
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-2409 http://www.scripps.edu/chem/yu/index/html
Search for more papers by this authorJin-Quan Yu Prof.
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-2409 http://www.scripps.edu/chem/yu/index/html
Search for more papers by this authorKeary M. Engle
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-2409 http://www.scripps.edu/chem/yu/index/html
Search for more papers by this authorDong-Hui Wang
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-2409 http://www.scripps.edu/chem/yu/index/html
Search for more papers by this authorJin-Quan Yu Prof.
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-2409 http://www.scripps.edu/chem/yu/index/html
Search for more papers by this authorWe gratefully acknowledge TSRI, the NIH (NIGMS, 1 R01 GM084019-02), Amgen, and Eli Lilly for financial support. We thank the A. P. Sloan Foundation for a fellowship (J.-Q.Y.) and the NSF, the DOD, TSRI, and the Skaggs Oxford Scholarship program for predoctoral fellowships (K.M.E.).
Graphical Abstract
Balanceakt: In den beschriebenen komplementären Katalysesystemen lassen sich Reaktivität und Selektivität bei PdII-katalysierten ortho-C-H-Olefinierungen gegeneinander abwägen, um den schnellen Aufbau der 1,2,3-trisubstituierten Arene 1 durch schrittweise C-H-Funktionalisierung zu ermöglichen. Außerdem gelang eine iterative C-H-Aktivierung so, dass eine neu eingeführte funktionelle Gruppe eine anschließende C-H-Aktivierung steuert (2).
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