Aufsatz
Epoxidöffnungskaskaden zur Synthese polycyclischer Polyether-Naturstoffe
Ivan Vilotijevic,
Timothy F. Jamison Prof. Dr.,
Ivan Vilotijevic
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA), Fax: (+1) 617-324-0253 http://web.mit.edu/chemistry/jamison
Search for more papers by this authorTimothy F. Jamison Prof. Dr.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA), Fax: (+1) 617-324-0253 http://web.mit.edu/chemistry/jamison
Search for more papers by this authorIvan Vilotijevic,
Timothy F. Jamison Prof. Dr.,
Ivan Vilotijevic
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA), Fax: (+1) 617-324-0253 http://web.mit.edu/chemistry/jamison
Search for more papers by this authorTimothy F. Jamison Prof. Dr.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA), Fax: (+1) 617-324-0253 http://web.mit.edu/chemistry/jamison
Search for more papers by this authorAbstract
Die polycyclischen Strukturelemente von Polyether-Naturstoffen können in einigen Fällen bis auf ihren Ursprung in der Biosynthese zurückverfolgt werden, in anderen, weniger gut verstandenen Fällen jedoch nur auf vorgeschlagene Biosynthesewege, die spekulative Epoxidöffnungskaskaden vorsehen. In diesem Aufsatz wird zusammengefasst, wie solche Reaktionskaskaden zur Synthese polycyclischer Polyether und verwandter Naturstoffe genutzt wurden.
Polycyclische Polyether-Naturstoffe sind wegen ihrer faszinierenden Struktur und ihrer biologischen Eigenschaften von besonderem Interesse. Letztere umfassen potenziell therapeutische antibiotische und fungizide Wirkungen sowie Antikrebswirkungen und außerdem eine starke Giftwirkung bis hin zur Letalität. Die polycyclischen Strukturelemente dieser Verbindungsklasse können in einigen Fällen bis auf ihren Ursprung in der Biosynthese zurückverfolgt werden, in anderen, weniger gut verstandenen Fällen jedoch nur auf vorgeschlagene Biosynthesewege, die spekulative Epoxidöffnungskaskaden vorsehen. In diesem Aufsatz wird zusammengefasst, wie solche Reaktionskaskaden zur Synthese polycyclischer Polyether und verwandter Naturstoffe genutzt wurden.
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