Highly Compatible Metal and Enzyme Catalysts for Efficient Dynamic Kinetic Resolution of Alcohols at Ambient Temperature†
Belén Martín-Matute Dr.
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10 691 Stockholm, Sweden, Fax: (+46) 8-154-908
Search for more papers by this authorMichaela Edin
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10 691 Stockholm, Sweden, Fax: (+46) 8-154-908
Search for more papers by this authorKrisztián Bogár
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10 691 Stockholm, Sweden, Fax: (+46) 8-154-908
Search for more papers by this authorJan-E. Bäckvall Prof. Dr.
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10 691 Stockholm, Sweden, Fax: (+46) 8-154-908
Search for more papers by this authorBelén Martín-Matute Dr.
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10 691 Stockholm, Sweden, Fax: (+46) 8-154-908
Search for more papers by this authorMichaela Edin
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10 691 Stockholm, Sweden, Fax: (+46) 8-154-908
Search for more papers by this authorKrisztián Bogár
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10 691 Stockholm, Sweden, Fax: (+46) 8-154-908
Search for more papers by this authorJan-E. Bäckvall Prof. Dr.
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10 691 Stockholm, Sweden, Fax: (+46) 8-154-908
Search for more papers by this authorWe are grateful for financial support from the Swedish Research Council, the Swedish Foundation for Strategic Research, and the Ministerio de Educación y Ciencia of Spain.
Graphical Abstract
Sehr kurze Reaktionszeiten bei Raumtemperatur: Die Kombination hochkompatibler Metall- und Enzymkatalysatoren ermöglichte die schnellste jemals beschriebene dynamische kinetische Racematspaltung bei Alkoholen. Mit dem Rutheniumkatalysator 1 a (oder 1 b) und einer immobilisierten Lipase gelang bei Raumtemperatur und in ausgezeichneter Ausbeute die effiziente enantioselektive Synthese von Acetaten (siehe Schema).
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