Synthese neuartiger 6-Amido-6-desoxy-L-galactose-Derivate als potente Sialyl-Lewisx-Mimetica†
Dr. Michael W. Cappi
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409
Search for more papers by this authorDr. Wilna J. Moree
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409
Search for more papers by this authorDr. Lei Qiao
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409
Search for more papers by this authorDr. Thomas G. Marron
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409
Search for more papers by this authorDr. Gabriele Weitz-Schmidt
Präklinische Forschung, Sandoz Pharmaceuticals Ltd. CH–4002 Basel (Schweiz)
Search for more papers by this authorCorresponding Author
Prof. Chi-Huey Wong
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409Search for more papers by this authorDr. Michael W. Cappi
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409
Search for more papers by this authorDr. Wilna J. Moree
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409
Search for more papers by this authorDr. Lei Qiao
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409
Search for more papers by this authorDr. Thomas G. Marron
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409
Search for more papers by this authorDr. Gabriele Weitz-Schmidt
Präklinische Forschung, Sandoz Pharmaceuticals Ltd. CH–4002 Basel (Schweiz)
Search for more papers by this authorCorresponding Author
Prof. Chi-Huey Wong
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409
Chemistry Department, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Telefax: Int. +619/784–2409Search for more papers by this authorDiese Arbeit wurde von der National Science Foundation (USA), von Sandoz Pharmaceuticals Ltd. und von der NATO (Stipendium für W. J. M.) gefördert.
Abstract
Bemerkenswert hohe Inhibierungskonstanten weisen Sialyl-Lewisx-(SLex)-Mimetica auf, die aus einer Aminosäure, einem Galactosamin und einer Carboxylat-tragenden Seitenkette bestehen. So beträgt der IC50-Wert von 1 0.2 mM, ist also nur etwa halb so groß wie der von SLex.
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