Lack of an association between apolipoprotein E ϵ4 and Alzheimer's disease in elderly nigerians
B. O. Osuntokun MD
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorA. Sahota PhD
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Search for more papers by this authorA. O. Ogunniyi MD
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorO. Gureje MD
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorO. Baiyewu MD
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorA. Adeyinka MBBS
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorS. O. Oluwole MBBS
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorO. Komolafe MBBS
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorK. S. Hall PhD
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Search for more papers by this authorF. W. Unverzagt PhD
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Search for more papers by this authorS. L. Hui PhD
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Search for more papers by this authorM. Yang MS
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Search for more papers by this authorCorresponding Author
Dr H. C. Hendrie MB, ChB
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Indiana University School of Medicine, Department of Psychiatry, 541 Clinical Drive, Rm 298, Indianapolis, IN 46202–5111Search for more papers by this authorB. O. Osuntokun MD
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorA. Sahota PhD
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Search for more papers by this authorA. O. Ogunniyi MD
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorO. Gureje MD
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorO. Baiyewu MD
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorA. Adeyinka MBBS
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorS. O. Oluwole MBBS
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorO. Komolafe MBBS
Neurology Unit, Department of Medicine, Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria
Search for more papers by this authorK. S. Hall PhD
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Search for more papers by this authorF. W. Unverzagt PhD
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Search for more papers by this authorS. L. Hui PhD
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Search for more papers by this authorM. Yang MS
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Search for more papers by this authorCorresponding Author
Dr H. C. Hendrie MB, ChB
Departments of Psychiatry, Medicine, and Genetics, Indiana University School of Medicine, Indianapolis, IN
Indiana University School of Medicine, Department of Psychiatry, 541 Clinical Drive, Rm 298, Indianapolis, IN 46202–5111Search for more papers by this authorAbstract
As part of a community-based study of Alzheimer's Disease (AD) in a Nigerian population aged 65 years and over, we have determined apolipoprotein E (APOE) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with AD). The ϵ4 allele of APOE was not associated with AD or dementia in this community-based sample. The ϵ4 allele frequency was 17.6% in demented patients and 16.7% in AD patients compared with 20.5% in the control subjects. These findings are in marked contrast to the strong association between the ϵ4 allele and AD in our previously reported study with African Americans.
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