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Decreased cerebrospinal fluid levels of β-endorphin in Japanese patients with Joseph disease

Corresponding Author

Dr. Toyojiro Matsuishi MD

Department of Pediatrics and Child Health, Kurume University School of Medicine Fukuoka, Japan

Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahimachi, Kurume City, Japan 830Search for more papers by this author

Tetsuo Sakai MD,

Tetsuo Sakai MD

Department of Neurology, National Ckikugo Hospital, Fukuoka, Japan

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Shinichiro Nagamitsu MD,

Shinichiro Nagamitsu MD

Department of Pediatrics and Child Health, Kurume University School of Medicine Fukuoka, Japan

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Hironori Komori MD,

Hironori Komori MD

Department of Pediatrics and Child Health, Kurume University School of Medicine Fukuoka, Japan

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Hiroshi Iwashita MD,

Hiroshi Iwashita MD

Department of Neurology, National Ckikugo Hospital, Fukuoka, Japan

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Hiroshisa Kato MD,

Hiroshisa Kato MD

Department of Pediatrics and Child Health, Kurume University School of Medicine Fukuoka, Japan

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Dr. Toyojiro Matsuishi MD,

Corresponding Author

Dr. Toyojiro Matsuishi MD

Department of Pediatrics and Child Health, Kurume University School of Medicine Fukuoka, Japan

Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahimachi, Kurume City, Japan 830Search for more papers by this author

Tetsuo Sakai MD,

Tetsuo Sakai MD

Department of Neurology, National Ckikugo Hospital, Fukuoka, Japan

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Shinichiro Nagamitsu MD,

Shinichiro Nagamitsu MD

Department of Pediatrics and Child Health, Kurume University School of Medicine Fukuoka, Japan

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Hironori Komori MD,

Hironori Komori MD

Department of Pediatrics and Child Health, Kurume University School of Medicine Fukuoka, Japan

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Hiroshi Iwashita MD,

Hiroshi Iwashita MD

Department of Neurology, National Ckikugo Hospital, Fukuoka, Japan

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Hiroshisa Kato MD,

Hiroshisa Kato MD

Department of Pediatrics and Child Health, Kurume University School of Medicine Fukuoka, Japan

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First published: September 1994

https://doi.org/10.1002/ana.410360317

Citations: 1

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Abstract

We measured the cerebrospinal fluid (CSF) levels of β-endorphin in 7 Japanese patients with Joseph disease and compared them with control values. The 7 patients included 4 with type I and 3 with type II disease; their mean age was 45.7 ± 12.09 years. Diseased controls were matched in age to the patients studied. In these patients, CSF β-endorphin level was significantly lower than in the controls (40% of normal values). An alteration in CSF β-endorphin level may explain some of the neurological impairment found in Joseph disease.

References

1 Rosenberg RN, Nyhan WL, Bay C, Shore P.: Autosomal dominant striatonigral degeneration: a clinical, pathologic, and biochemical study of a new genetic disorder. Neurology 1976; 26: 703–714
10.1212/WNL.26.8.703
PubMed Web of Science® Google Scholar
2 Coutinho P, Andrade C.: Autosomal dominant system degeneration in Portuguese families of the Azores islands: a new genetic disorder involving cerebellar, pyramidal, extrapyramidal and spinal cord motor functions. Neurology 1978; 28: 703–709
10.1212/WNL.28.7.703
CAS PubMed Web of Science® Google Scholar
3 Rosenberg RN Joseph disease: an autosomal dominant motor system degeneration.: In: JMBV de Jong, ed. Handbook of clinical neurology, vol 16 (60). Hereditary neuropathies and spinocerebellar atrophies. Amsterdam: Elsevier, 1991; 467–479
Google Scholar
4 Sakai T, Oda K.: Abundant reinnervation in peripheral nerves in Joseph disease. Neurology 1993; 43: 428–430
10.1212/WNL.43.2.428
CAS PubMed Web of Science® Google Scholar
5 Takiyama Y, Nishizawa M, Tanaka H, et al.: The gene for Machado-Joseph disease maps to human chromosome 14q. Nature Genet 1993; 4: 300–304
10.1038/ng0793-300
CAS PubMed Web of Science® Google Scholar
6 Sakai T, Ohta M, Ishino H.: Joseph disease in a non-Portuguese family. Neurology 1983; 33: 74–80
10.1212/WNL.33.1.74
CAS PubMed Web of Science® Google Scholar
7 Kitamura J, Kubuki Y, Tsuruta T, et al.: A new family with Joseph disease in Japan. Homovanillic acid, magnetic resonance, and sleep apnea studies. Arch Neurol 1988; 46: 425–428
10.1001/archneur.1989.00520400085024
Web of Science® Google Scholar
8 Frederickson RC, Geary LE.: Endogeneous opioid peptides: review of physiological, pharmacological and clinical aspects. Prog Neurobiol 1982; 19: 19–62
10.1016/0301-0082(82)90020-X
CAS PubMed Web of Science® Google Scholar
9 Domscher W, Dickschas A, Mitznegg P.: CSF β-endorphin in schizophrenia. Lancet 1979; 1: 1024 (Letter)
10.1016/S0140-6736(79)92769-7
Google Scholar
10 Gillberg C, Terenius L, Lönnerholm G.: Endorphin activity in childhood psychosis: spinal fluid levels in 24 cases. Arch Gen Psychiatry 1985; 42: 780–783
10.1001/archpsyc.1985.01790310042005
PubMed Web of Science® Google Scholar
11 Myer EC, Tripathi HL, Brase DA, William LD.: Elevated CSF beta-endorphin immunoreactivity in Rett's syndrome: report of 158 cases and comparison with leukemic children. Neurology 1992; 42: 357–360
10.1212/WNL.42.2.357
CAS PubMed Web of Science® Google Scholar
12 Nagamitsu S.: CSF beta-endorphin levels in pediatric neurologic disorders. Kurume Med J 1993; 40: 233–241
10.2739/kurumemedj.40.233
CAS PubMed Google Scholar
13 Van Loon GR, Ho D, Kim C.: β-Endorphin-induced decrease in hypothalamic dopamine turnover. Endocrinology 1980; 106: 76–80
10.1210/endo-106-1-76
CAS PubMed Web of Science® Google Scholar
14 Van Loon GR, De Souza EB.: Effects of β-endorphin on brain serotonin metabolism. Life Sci 1978; 23: 971–978
10.1016/0024-3205(78)90224-2
CAS PubMed Web of Science® Google Scholar
15 Bach FW, Schmidt JF, Faber T.: Radioimmunoassay of β-endorphin in ventricular and lumbar cerebrospinal fluid. Clin Chem 1992; 38: 847–852
CAS PubMed Web of Science® Google Scholar

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Volume36, Issue3

September 1994

Pages 441-443

Decreased cerebrospinal fluid levels of β-endorphin in Japanese patients with Joseph disease

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Decreased cerebrospinal fluid levels of β-endorphin in Japanese patients with Joseph disease

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