Systemic histiocytosis presenting as multiple sclerosis
Corresponding Author
Dr. M. E. Smith MD
Neuroimmunology Branch National Institutes of Health, Bethesda, MD
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5B-16, 9000 Rockville Pike, Bethesda, MD 20892Search for more papers by this authorD. A. Katz MD
Office of the Clinical Director, NINDS, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
Search for more papers by this authorJ. O. Harris MD
Neuroimmunology Branch National Institutes of Health, Bethesda, MD
Search for more papers by this authorJ. A. Frank MD
The Diagnostic Radiology Research Program, National Institutes of Health, Bethesda, MD
Search for more papers by this authorC. V. Kufta MD
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD
Search for more papers by this authorD. E. McFarlin MD
Neuroimmunology Branch National Institutes of Health, Bethesda, MD
Search for more papers by this authorCorresponding Author
Dr. M. E. Smith MD
Neuroimmunology Branch National Institutes of Health, Bethesda, MD
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5B-16, 9000 Rockville Pike, Bethesda, MD 20892Search for more papers by this authorD. A. Katz MD
Office of the Clinical Director, NINDS, and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
Search for more papers by this authorJ. O. Harris MD
Neuroimmunology Branch National Institutes of Health, Bethesda, MD
Search for more papers by this authorJ. A. Frank MD
The Diagnostic Radiology Research Program, National Institutes of Health, Bethesda, MD
Search for more papers by this authorC. V. Kufta MD
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD
Search for more papers by this authorD. E. McFarlin MD
Neuroimmunology Branch National Institutes of Health, Bethesda, MD
Search for more papers by this authorAbstract
A Patient resembling one with progressive multiple sclerosis in clinical presentation and by magnetic resonance imaging was studied in detail. Some features atypical for multiple sclerosis prompted a persistent search for an alternative cause. The diagnosis of a non-Langerhans systemic histiocytosis involving brain and bone was established and showed a partial response to radiation therapy. This patient illustrates the continued importance of a broad approach to the evaluation of possible multiple sclerosis, with particular attention to atypical features.
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