Annals of Neurology: Volume 84, Number 3, September 2018

An electron micrograph of a blood vessel in the cerebral cortex of a mouse 6 hours after cortical spreading depression. The animal received an intravenous injection of horseradish peroxidase (dark) which fills the blood vessel. Transudation of fluid from the lumen of the vessel occurs via vesicular transport (small black vesicles making their way from the lumen to the surface), not by opening of endothelial tight junctions. See Sadeghian, et al., pages 409–423. Ann Neurol 2018;84:1–1