Combinatorial Synthesis of Alkaloid‐like Compounds In Search of Chemical Probes of Protein‐Protein Interactions - Modern Alkaloids - Wiley Online Library

Combinatorial Synthesis of Alkaloid-like Compounds In Search of Chemical Probes of Protein-Protein Interactions

Michael Prakesch

National Research Council of Canada, Steacie Institute for Molecular Sciences, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada

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Prabhat Arya,

Prabhat Arya

National Research Council of Canada, Steacie Institute for Molecular Sciences, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada

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Marwen Naim,

Marwen Naim

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Traian Sulea,

Traian Sulea

Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Quebec, H4P 2R2, Canada

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Enrico Purisima,

Enrico Purisima

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Aleksey Yu. Denisov,

Aleksey Yu. Denisov

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Kalle Gehring,

Kalle Gehring

Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G IV6, Canada

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Trina L. Foster,

Trina L. Foster

Apoptosis Research Centre, Children's Hospital of Eastern Ontario (CHEO), 401 Smyth Road, Ottawa K1H 8L1, Canada

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Robert G. Korneluk,

Robert G. Korneluk

National Research Council of Canada, Steacie Institute for Molecular Sciences, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada

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Michael Prakesch,

Michael Prakesch

National Research Council of Canada, Steacie Institute for Molecular Sciences, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada

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Prabhat Arya,

Prabhat Arya

National Research Council of Canada, Steacie Institute for Molecular Sciences, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada

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Marwen Naim,

Marwen Naim

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Traian Sulea,

Traian Sulea

Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Quebec, H4P 2R2, Canada

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Enrico Purisima,

Enrico Purisima

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Aleksey Yu. Denisov,

Aleksey Yu. Denisov

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Kalle Gehring,

Kalle Gehring

Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G IV6, Canada

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Trina L. Foster,

Trina L. Foster

Apoptosis Research Centre, Children's Hospital of Eastern Ontario (CHEO), 401 Smyth Road, Ottawa K1H 8L1, Canada

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Robert G. Korneluk,

Robert G. Korneluk

National Research Council of Canada, Steacie Institute for Molecular Sciences, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada

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Book Editor(s):Prof. Ernesto Fattorusso,

Prof. Ernesto Fattorusso

Università di Napoli “Federico II”, Dipartimento di Chimica delle Sostanze Naturali, Via D. Montesano, 49, 80131 Napoli, Italy

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Prof. Orazio Taglialatela-Scafati,

Prof. Orazio Taglialatela-Scafati

Università di Napoli “Federico II”, Dipartimento di Chimica delle Sostanze Naturali, Via D. Montesano, 49, 80131 Napoli, Italy

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First published: 24 October 2007

https://doi.org/10.1002/9783527621071.ch17

Citations: 1

Summary

This chapter contains sections titled:

Introduction
Protein-Protein Interactions
Alkaloid Natural Products as Chemical Probes of Protein-Protein Interactions
Indoline Alkaloid Natural Product-inspired Chemical Probes
- Indoline Alkaloid-inspired Chemical Probes
  - Tetrahydroquinoline Alkaloid-inspired Chemical Probes
- Alkaloid Natural Product-inspired Small-molecule Binders to Bcl-2 and Bcl-XL and In Silico Studies
  - Alkaloid Natural Product-inspired Small-molecule Binders to Bcl-XL and NMR Studies
  - Alkaloid Natural Product-inspired Small-molecule Probes for XIAP
    - Cell Death Assay
    - Caspase-3 Activation Assay
    - Caspase-9 Release Assay
  - Summary and Future Outlook
- Acknowledgments

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Citing Literature

Modern Alkaloids: Structure, Isolation, Synthesis and Biology