Chapter 11

Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography, and Non-Mass-Spectrometric Detection

Mark Hayward

Mark Hayward

Analytical, Automation, and Formulation Laboratories, Department of Chemistry, Lundbeck Research USA, Paramus, New Jersey, USA

Department of Chemistry, Lundbeck Research USA, Paramus, New Jersey, USA

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Maria D. Bacolod

Maria D. Bacolod

Department of Chemistry, Lundbeck Research USA, Paramus, New Jersey, USA

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Qing Ping Han

Qing Ping Han

Department of Chemistry, Lundbeck Research USA, Paramus, New Jersey, USA

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Manuel Cajina

Manuel Cajina

Department of Chemistry, Lundbeck Research USA, Paramus, New Jersey, USA

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Zack Zou

Zack Zou

Department of Chemistry, Lundbeck Research USA, Paramus, New Jersey, USA

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First published: 14 March 2011

Summary

This chapter contains sections titled:

  • Introduction

  • Sample Preparation for Bioanalysis

  • Sample Preparation for Metabolite Profiling and Identification

  • Liquid Chromatographic Separation in Bioanalysis

  • Liquid Chromatographic Separation Technologies in Metabolite Profiling

  • Liquid Chromatographic Detection

  • References

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