Volume 45, Issue 4 pp. 515-518
Brief Communication

Functional magnetic resonance imaging evidence for task-specific activation of developmentally abnormal visual association cortex

Charles D. Smith MD

Corresponding Author

Charles D. Smith MD

Department of Neurology, University of Kentucky College of Medicine, Lexington, KY

Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington, KY

Room 113, MRISC Building, University of Kentucky Medical Center, Lexington, KY 40536Search for more papers by this author
Edwin R. Trevathan MD

Edwin R. Trevathan MD

Department of Neurology, University of Kentucky College of Medicine, Lexington, KY

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Ming Zhang PhD

Ming Zhang PhD

Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington, KY

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Anders H. Andersen PhD

Anders H. Andersen PhD

Department of Biomedical Engineering, University of Kentucky College of Medicine, Lexington, KY

Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington, KY

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Malcolm J. Avison PhD

Malcolm J. Avison PhD

Department of Neurology, University of Kentucky College of Medicine, Lexington, KY

Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington, KY

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Abstract

Functional magnetic resonance imaging was performed on a 36-year-old woman with muscular dystrophy, intractable epilepsy, and bilateral temporo-occipital lissencephaly. We observed islands of task-specific activation in lissencephalic cortex homologous to visual association regions activated in normal subjects on the same visual confrontation naming task. This result suggests lissencephalic cortex may develop specific functional connections with other brain regions. Ann Neurol 1999;45:515–518

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