Volume 38, Issue 13-14 pp. 1993-1996
Communication

Identification of Sequence-Selective Receptors for Peptides with a Carboxylic Acid Terminus

Thilo Fessmann

Thilo Fessmann

Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ (UK), Fax: (+44) 1703-593781

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Jeremy D. Kilburn

Jeremy D. Kilburn

Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ (UK), Fax: (+44) 1703-593781

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Abstract

A combinatorial library of “tweezer” receptors, which incorporate a diamidopyridine unit to provide a specific binding site for a CO2H group (see picture), can be screened to identify sequence-selective receptors for chosen peptide guests with a CO2H terminus.

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