A Giant Carceplex Permanently Entraps Three Organic Molecules

Capping a trimer of cavitands at the top and bottom creates a large carceplex which contains three permanently entrapped N,N-dimethylformamide (DMF) molecules (shown schematically). Room-temperature NMR spectra and CPK models indicate that the DMF molecules are free to move within the carceplex cavity and thus create a “microsolvent” environment, while at lower temperatures distinct DMF sites can be distinguished.