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Short step enantioselective synthesis of (−)-swainsonine
T. Punniyamurthy,
Ryo Irie,
Tsutomu Katsuki,
T. Punniyamurthy
Department of Molecular Chemistry, Graduate School of Science, Kyushu University, Fukuoka, Japan
Search for more papers by this authorRyo Irie
Department of Molecular Chemistry, Graduate School of Science, Kyushu University, Fukuoka, Japan
Search for more papers by this authorCorresponding Author
Tsutomu Katsuki
Department of Molecular Chemistry, Graduate School of Science, Kyushu University, Fukuoka, Japan
Department of Molecular Chemistry, Graduate School of Science, Kyushu University 33, Hakozaki, Higashi-ku, Fukuoka 812-8581, JapanSearch for more papers by this authorT. Punniyamurthy,
Ryo Irie,
Tsutomu Katsuki,
T. Punniyamurthy
Department of Molecular Chemistry, Graduate School of Science, Kyushu University, Fukuoka, Japan
Search for more papers by this authorRyo Irie
Department of Molecular Chemistry, Graduate School of Science, Kyushu University, Fukuoka, Japan
Search for more papers by this authorCorresponding Author
Tsutomu Katsuki
Department of Molecular Chemistry, Graduate School of Science, Kyushu University, Fukuoka, Japan
Department of Molecular Chemistry, Graduate School of Science, Kyushu University 33, Hakozaki, Higashi-ku, Fukuoka 812-8581, JapanSearch for more papers by this authorFirst published: 19 May 2000
Citations: 15
Abstract
Recent discovery of asymmetric desymmetrization of meso-heterocycles using (R,R)-(salen)manganese complex 2 as a catalyst allowed easy access to optically active 2,3,4-trisubstituted pyrrolidines. Taking advantage of this new reaction, we could achieve the short-step synthesis of (−)-swainsonine 1. Chirality 12:464–468, 2000. © 2000 Wiley-Liss, Inc.
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