Full Paper
Asymmetric synthesis of 1,2-amino alcohols using (S)-indoline chiral auxiliary
So Won Youn,
Jun Young Choi,
Yong Hae Kim,
So Won Youn
Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon, Korea
Search for more papers by this authorJun Young Choi
Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon, Korea
Search for more papers by this authorCorresponding Author
Yong Hae Kim
Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon, Korea
Department of Chemistry, Korea Advanced Institute of Science and Technology, 373-1, Kusong Dong, Yusong Gu, Taejon, 305-701, KoreaSearch for more papers by this authorSo Won Youn,
Jun Young Choi,
Yong Hae Kim,
So Won Youn
Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon, Korea
Search for more papers by this authorJun Young Choi
Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon, Korea
Search for more papers by this authorCorresponding Author
Yong Hae Kim
Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon, Korea
Department of Chemistry, Korea Advanced Institute of Science and Technology, 373-1, Kusong Dong, Yusong Gu, Taejon, 305-701, KoreaSearch for more papers by this authorFirst published: 19 May 2000
Citations: 4
Abstract
Chiral hydrazones 1 reacted with aryl- or alkyl-lithiums at −78°C in a short reaction time, within 10 min, to afford arylated or alkylated chiral hydrazines 3 with extremely high diastereoselectivity (up to >99% de) and high chemical yields. The hydrazines are readily converted to chiral amino alcohols 4. Chirality 12:404–407, 2000. © 2000 Wiley-Liss, Inc.
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