Maternal Carriage of Prevotella copri Is Associated With Increased Thymus Derived Naïve Regulatory T Cells in Cord Blood
Yuan Gao
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia
Child Health Research Unit, Barwon Health, Geelong, Australia
Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Search for more papers by this authorMartin O'Hely
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia
Child Health Research Unit, Barwon Health, Geelong, Australia
Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia
Search for more papers by this authorFiona Collier
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia
Search for more papers by this authorAnne-Louise Ponsonby
Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia
Florey Institute for Neuroscience and Mental Health, Melbourne, Australia
Search for more papers by this authorMimi L. K. Tang
Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia
Department of Pediatrics, University of Melbourne, Melbourne, Australia
Search for more papers by this authorJohn Molloy
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia
Child Health Research Unit, Barwon Health, Geelong, Australia
Search for more papers by this authorCorresponding Author
Peter Vuillermin
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia
Child Health Research Unit, Barwon Health, Geelong, Australia
Correspondence:
Peter Vuillermin ([email protected])
Search for more papers by this authorthe BIS Investigator Group
Search for more papers by this authorYuan Gao
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia
Child Health Research Unit, Barwon Health, Geelong, Australia
Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Search for more papers by this authorMartin O'Hely
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia
Child Health Research Unit, Barwon Health, Geelong, Australia
Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia
Search for more papers by this authorFiona Collier
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia
Search for more papers by this authorAnne-Louise Ponsonby
Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia
Florey Institute for Neuroscience and Mental Health, Melbourne, Australia
Search for more papers by this authorMimi L. K. Tang
Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia
Department of Pediatrics, University of Melbourne, Melbourne, Australia
Search for more papers by this authorJohn Molloy
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia
Child Health Research Unit, Barwon Health, Geelong, Australia
Search for more papers by this authorCorresponding Author
Peter Vuillermin
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia
Child Health Research Unit, Barwon Health, Geelong, Australia
Correspondence:
Peter Vuillermin ([email protected])
Search for more papers by this authorthe BIS Investigator Group
Search for more papers by this authorFunding: This work was supported by the National Health and Medical Research Council of Australia (grant numbers 1082307 and 1147980), the Australian Food Allergy Foundation, The Murdoch Children's Research Institute, Barwon Health Foundation and Deakin University.
Open Research
Data Availability Statement
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Supporting Information
| Filename | Description |
|---|---|
| imm13904-sup-0001-Supinfo.docxWord 2007 document , 21.9 KB |
Data S1. Supporting Information. |
| imm13904-sup-0002-TableS1.xlsxExcel 2007 spreadsheet , 10.5 KB |
Table S1. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1 P. J. Vuillermin, M. O'Hely, F. Collier, et al., “Maternal Carriage of Prevotella During Pregnancy Associates With Protection Against Food Allergy in the Offspring,” Nature Communications 11, no. 1 (2020): 1452–1457.
- 2 P. Kovatcheva-Datchary, A. Nilsson, R. Akrami, et al., “Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated With Increased Abundance of Prevotella,” Cell Metabolism 22, no. 6 (2015): 971–982.
- 3 M. Hu, D. Eviston, P. Hsu, et al., “Decreased Maternal Serum Acetate and Impaired Fetal Thymic and Regulatory T Cell Development in Preeclampsia,” Nature Communications 10, no. 1 (2019): 1–13.
- 4 M. Noval Rivas, O. T. Burton, P. Wise, et al., “Regulatory T Cell Reprogramming Toward a Th2-Cell-Like Lineage Impairs Oral Tolerance and Promotes Food Allergy,” Immunity 42, no. 3 (2015): 512–523.
- 5 F. Collier, A. L. Ponsonby, M. O'Hely, et al., “Naïve Regulatory T Cells in Infancy: Associations With Perinatal Factors and Development of Food Allergy,” Allergy 74, no. 9 (2019): 1760–1768.
- 6 P. Vuillermin, R. Saffery, K. J. Allen, et al., “Cohort Profile: The Barwon Infant Study,” International Journal of Epidemiology 44, no. 4 (2015): 1148–1160.
- 7 L. Gray, K. Hasebe, M. O'Hely, A.-L. Ponsonby, P. Vuillermin, and F. Collier, “Rapid PCR Identification of Prevotella copri in an Australian Cohort of Pregnant Women,” Journal of Developmental Origins of Health and Disease 11, no. 3 (2020): 228–234.
- 8 Y. Gao, R. Nanan, L. Macia, et al., “The Maternal Gut Microbiome During Pregnancy and Offspring Allergy and Asthma,” Journal of Allergy and Clinical Immunology 148, no. 3 (2021): 669–678.
