Antimicrobial peptides in hidradenitis suppurativa: a systematic review*
Y. Yao
Department of Dermato-Venereology and Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark
Contribution: Conceptualization (supporting), Data curation (equal), Formal analysis (lead), Investigation (equal), Methodology (lead)
Search for more papers by this authorJ.W. Frew
Department of Dermatology, Liverpool Hospital, Sydney, Australia
University of New South Wales, Sydney, Australia
Dermatology Research Group, Ingham Institute of Applied Medical Research, Sydney, Australia
Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - review & editing (equal)
Search for more papers by this authorS.F. Thomsen
Department of Dermato-Venereology and Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Contribution: Conceptualization (supporting), Data curation (equal), Formal analysis (equal), Investigation (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
H.C. Ring
Department of Dermato-Venereology and Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark
Correspondence
Hans Christian Ring.
Email: [email protected]
Contribution: Conceptualization (lead), Data curation (equal), Formal analysis (equal), Investigation (equal), Writing - review & editing (equal)
Search for more papers by this authorY. Yao
Department of Dermato-Venereology and Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark
Contribution: Conceptualization (supporting), Data curation (equal), Formal analysis (lead), Investigation (equal), Methodology (lead)
Search for more papers by this authorJ.W. Frew
Department of Dermatology, Liverpool Hospital, Sydney, Australia
University of New South Wales, Sydney, Australia
Dermatology Research Group, Ingham Institute of Applied Medical Research, Sydney, Australia
Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - review & editing (equal)
Search for more papers by this authorS.F. Thomsen
Department of Dermato-Venereology and Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Contribution: Conceptualization (supporting), Data curation (equal), Formal analysis (equal), Investigation (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
H.C. Ring
Department of Dermato-Venereology and Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark
Correspondence
Hans Christian Ring.
Email: [email protected]
Contribution: Conceptualization (lead), Data curation (equal), Formal analysis (equal), Investigation (equal), Writing - review & editing (equal)
Search for more papers by this authorPlain language summary available online
Summary
Background
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease of the hair follicle defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. HS is associated with microbial dysbiosis and immune dysregulation. In HS, an increasing number of studies have investigated antimicrobial peptides (AMPs).
Objectives
To provide an overview of the literature on AMPs in HS, and to discuss the potential role of AMPs in the pathogenesis of HS.
Methods
PubMed, Embase and the Cochrane Library were searched. The titles, abstracts and full texts of all articles were manually screened. Additionally, the reference lists of the included articles were screened and hand searched for relevant studies.
Results
The final literature sample comprised 18 retrospective and prospective studies (no reviews or commentaries) published between 2009 and 2020.
Conclusions
This review demonstrates the multitude of AMPs in HS. Although the methodology of the studies varied, the included studies indicate a consistent overexpression of human β-defensin (hBD)-2, S100A7, S100A8 and S100A9 at both the mRNA and protein levels, and a decreased expression of hBD-1. Overall, the studies point to a dysregulation of AMPs in both lesional and nonlesional HS skin.
Supporting Information
| Filename | Description |
|---|---|
| bjd20750-sup-0001-TableS1-S6.docxWord 2007 document , 69.4 KB |
Table S1 Studies on human β-defensin 2 in hidradenitis suppurativa. Table S2 Studies on S100A7 in hidradenitis suppurativa. Table S3 Studies on S100A8 and S100A9 in hidradenitis suppurativa. Table S4 Studies on other antimicrobial peptides in hidradenitis suppurativa. Table S5 Studies on human β-defensin 1 in hidradenitis suppurativa. Table S6 Studies on human β-defensin 3 in hidradenitis suppurativa. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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