Efficacy and safety of topical Streptococcus postbiotic emollient in adolescents and adults with mild-to-moderate atopic dermatitis: A randomized, double-blind, vehicle-controlled trial
Min Seo Kim
Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Search for more papers by this authorHyeon Jin Kim
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea
Department of Regulatory Science, Kyung Hee University, Seoul, South Korea
Search for more papers by this authorSo Min Kang
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea
Search for more papers by this authorYoung Mok Heo
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorJiseung Kang
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorTae Kyeong Ryu
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea
Search for more papers by this authorHyun Jeong Kim
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea
Search for more papers by this authorYoung-Bong Choi
Department of Chemistry, Dankook University, Cheonan, South Korea
Search for more papers by this authorSol Kim
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorYoun Hwa Nho
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorSeunghyun Kang
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorLee Smith
Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Search for more papers by this authorAi Koyanagi
Research and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain
Search for more papers by this authorNikolaos G. Papadopoulos
Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece
Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty or Biology, Medicine and Health, The University of Manchester, Manchester, UK
Search for more papers by this authorHyungwoo Jo
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorDong-Geol Lee
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorJung U Shin
Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea
Search for more papers by this authorCorresponding Author
Dong Keon Yon
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea
Department of Regulatory Science, Kyung Hee University, Seoul, South Korea
Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea
Correspondence
Dong Keon Yon, Department of Pediatrics, Kyung Hee University College of Medicine 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea.
Email: [email protected]
Search for more papers by this authorMin Seo Kim
Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Search for more papers by this authorHyeon Jin Kim
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea
Department of Regulatory Science, Kyung Hee University, Seoul, South Korea
Search for more papers by this authorSo Min Kang
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea
Search for more papers by this authorYoung Mok Heo
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorJiseung Kang
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorTae Kyeong Ryu
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea
Search for more papers by this authorHyun Jeong Kim
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea
Search for more papers by this authorYoung-Bong Choi
Department of Chemistry, Dankook University, Cheonan, South Korea
Search for more papers by this authorSol Kim
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorYoun Hwa Nho
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorSeunghyun Kang
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorLee Smith
Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Search for more papers by this authorAi Koyanagi
Research and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain
Search for more papers by this authorNikolaos G. Papadopoulos
Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece
Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty or Biology, Medicine and Health, The University of Manchester, Manchester, UK
Search for more papers by this authorHyungwoo Jo
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorDong-Geol Lee
Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea
Department of Microbiology, Dankook University, Cheonan, South Korea
Search for more papers by this authorJung U Shin
Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea
Search for more papers by this authorCorresponding Author
Dong Keon Yon
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea
Department of Regulatory Science, Kyung Hee University, Seoul, South Korea
Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea
Correspondence
Dong Keon Yon, Department of Pediatrics, Kyung Hee University College of Medicine 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea.
Email: [email protected]
Search for more papers by this authorMin Seo Kim, Hyeon Jin Kim, So Min Kang, Young Mok Heo, and Jiseung Kang contributed equally to this work.
Dong-Geol Lee, Jung U Shin, and Dong Keon Yon contributed equallyto this work.
Open Research
DATA AVAILABILITY STATEMENT
A complete de-identified patient-level data set will be made available to researchers for the purpose of meta-analysis or a newly proposed study. Data will be made available following submission of a maximum 5-page proposal by the requestor. The study steering committee will review and, if acceptable, provide approval of the request. A signed data sharing access agreement will be required. The data will be provided as SAS or Excel datasets. Any other format requests may incur costs to the requestor. Data requests should be sent to [email protected]. Data will become available one year after publication of the initial study results.
Supporting Information
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Data S1. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
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- 5Park CW, Kim BJ, Lee YW, et al. Asivatrep, a TRPV1 antagonist, for the topical treatment of atopic dermatitis: phase 3, randomized, vehicle-controlled study (CAPTAIN-AD). J Allergy Clin Immunol. 2022; 149(4): 1340-1347.e4.
- 6Bieber T. Atopic dermatitis: an expanding therapeutic pipeline for a complex disease. Nat Rev Drug Discov. 2022; 21(1): 21-40.
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