Differences in health-related quality of life between European and Asian patients with hepatocellular carcinoma
Grant support: This study was funded in part by the EORTC Quality of Life Group. JMB is funded in part by the MRC ConDuCT Hub. WCC is funded by the National Science Council, Taiwan, No. NSC97-2314-B002-020-MY3. HCC is funded by the National Science Council, Taiwan, NSC 95-2314-B-037-079-MY3.
Conflicts of interest: none.
Competing interests: none.
Abstract
Aim
The aim of this study is to explore the possible effects of clinical and cultural characteristics of hepatocellular carcinoma on patients’ health-related quality of life (HRQoL).
Methods
Patients with hepatocellular carcinoma from Asian and European countries completed the EORTC QLQ-C30 and the EORTC QLQ-HCC18. Comparisons were made using Student's t-test and Wilcoxon rank-sum test with method of false discovery to correct multiple comparisons. Multiway analysis of variance and model selection were used to assess the effects of clinical characteristics and geographic areas.
Results
Two hundred and twenty-seven patients with hepatocellular carcinoma completed questionnaires. After adjusting for demographic and clinical characteristics, Asian patients still had significantly better HRQoL scores in emotional functioning, insomnia, (QLQ-C30) and in sexual interest (QLQ-HCC18). We also found an interaction in physical functioning (QLQ-C30) and fatigue (QLQ-HCC18) between geographic region and marital status, married European had worse HRQoL scores than Asian singles.
Conclusions
Both clinical characteristics and geographic areas affected the HRQoL in with hepatocellular carcinoma. Cultural differences and clinical differences in the pattern of disease due to active surveillance of Asian countries may explain the results.
