Characteristics of youth with type 1 diabetes (T1D) with and without a parent with T1D in the T1D exchange clinic registry
在1型糖尿病(type 1 diabetes,T1D)临床交流记录本中有1名父母合并或者不合并T1D的年轻T1D患者的特征
Abstract
enBackground
The aim of the present study was to compare characteristics and diabetes management in children and adolescents with and without at least one parent with type 1 diabetes (T1D).
Methods
In all, 12 890 participants aged <18 years at enrollment in the T1D Exchange Registry were included in the present study. Statistical comparisons between those with and without parental T1D were conducted using a univariate generalized linear mixed model.
Results
Of the study participants, 1056 (8.2%) registrants had at least one parent with T1D. Those with parental T1D were slightly, albeit significantly, younger (6.3 vs 6.9 years; P < 0.001) and less likely to have diabetic ketoacidosis (DKA) at diagnosis (24% vs 41%; P < 0.001) than those without parental T1D. There were no differences between groups in HbA1c, use of continuous glucose monitoring or insulin pump therapy, or the development of severe hypoglycemia or DKA. In addition, there were no differences found when comparing characteristics or diabetes management in those with a mother versus those with a father with T1D.
Conclusions
Children and adolescents with parental T1D tend to be diagnosed earlier. Diabetes management, glycemic control, and acute complications are similar in those with and without parental T1D.
Abstract
zh背景:
当前这项研究的目的是在至少有1名父母合并或者不合并1型糖尿病(T1D)的儿童以及青少年T1D患者中对比他们的特征以及糖尿病管理情况。
方法:
总共有12890名在T1D交流记录本中登记的年龄< 18岁的参与者被纳入了当前这项研究。在那些父母合并或者不合并T1D的患者之间使用单变量广义线性混合模型来统计对比。
结果:
在研究参与者中,有1056名(8.2%)登记者至少有1名父母合并T1D。与父母没有合并T1D的患者相比较,父母合并T1D的患者年龄稍小,但是有显著性差异(分别为6.3与6.9岁;P < 0.001),并且在诊断时更少合并糖尿病酮症酸中毒(分别为24%与41%;P < 0.001)。两组之间的HbA1c、动态血糖监测或者胰岛素泵治疗的使用率,以及严重低血糖或者DKA的发生率都没有差异。另外,那些母亲合并T1D的患者与那些父亲合并T1D的患者相比,没有发现他们的特征或者糖尿病控制情况有所差异。
结论:
父母合并T1D的儿童与青少年患者得到诊断的时间更早。在父母合并或者不合并T1D的患者之间,他们的糖尿病管理、血糖控制以及急性并发症都相类似。
