Bulk-solvent correction for fast translation search in molecular replacement: service programs for AMoRe and CNS

A new software package, BULK, was developed to allow fast and easy use of low-resolution data for the translation problem in molecular replacement. When the search model is relatively complete but not precise, or when its orientation is imprecisely determined, low-resolution data contribute very favourably to the solution of the translation-search problem. BULK comprises a specially developed program and a set of procedures complementary to the program AMoRe, as well as an input file for the CNS suite.