Double-Edged Dissolving Microneedle Patches Loaded with Zn/Ce Composites and Vancomycin for Treatment of Drug-Resistant Bacterial Infected Skin Abscess
Yu Jin
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Search for more papers by this authorZhaoyou Chu
Department of Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032 P. R. China
Search for more papers by this authorPengfei Zhu
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Search for more papers by this authorYechun Jiang
School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032 P. R. China
Search for more papers by this authorHui Shen
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Search for more papers by this authorYujie Wang
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Search for more papers by this authorSilong Wu
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Search for more papers by this authorMiaomiao Yang
Department of Pathology, Public Health Clinical Center, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032 P. R. China
Search for more papers by this authorCorresponding Author
Haisheng Qian
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Anhui Engineering Research Center for Medical Micro-Nano Devices, Anhui Medical University, Hefei, Anhui, 230011 P. R. China
Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, Anhui, 230601 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Yan Ma
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorYu Jin
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Search for more papers by this authorZhaoyou Chu
Department of Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032 P. R. China
Search for more papers by this authorPengfei Zhu
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Search for more papers by this authorYechun Jiang
School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032 P. R. China
Search for more papers by this authorHui Shen
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Search for more papers by this authorYujie Wang
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Search for more papers by this authorSilong Wu
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Search for more papers by this authorMiaomiao Yang
Department of Pathology, Public Health Clinical Center, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032 P. R. China
Search for more papers by this authorCorresponding Author
Haisheng Qian
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
Anhui Engineering Research Center for Medical Micro-Nano Devices, Anhui Medical University, Hefei, Anhui, 230011 P. R. China
Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, Anhui, 230601 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Yan Ma
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorAbstract
The management of abscess wounds induced by antibiotic-resistant bacterial infections has become increasingly formidable due to the widespread overutilization and misuse of antimicrobial agents. This study presents an innovative dissolvable microneedle (MN) patch incorporating Au@ZnO/Ce nanocomposites and vancomycin (AZC/Van@MN), exhibiting robust antimicrobial and anti-inflammatory properties, meticulously engineered for the therapeutic intervention of abscess wounds. The developed AZC/Van@MN patch demonstrates exceptional biocompatibility as evidenced by comprehensive histopathological and hematological assessments. It effectively eradicates bacterial colonies through the synergistic action of Van and mild photothermal therapy (PTT, ≤42 °C). Transcriptomic analysis elucidates that the antibacterial mechanism involves the upregulation of riboflavin biosynthesis and the suppression of arginine biosynthesis pathways. Furthermore, AZC/Van@MN significantly reduces abscess dimensions, bacterial load, and inflammatory response, while simultaneously enhancing wound healing via accelerated re-epithelialization and angiogenesis. This double-edged MN patch represents a promising strategy for combating skin abscesses instigated by antibiotic-resistant bacteria.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
Supporting Information
| Filename | Description |
|---|---|
| smll202412165-sup-0001-SuppMat.docx11.8 MB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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