Small
Volume 19, Issue 48 2370404
Frontispiece
Free Access

Positron Emission Tomography Studies of the Biodistribution, Translocation, and Fate of Poly Allyl Amine-Based Carriers for Sirna Delivery by Systemic and Intratumoral Administration (Small 48/2023)

Cristina Simo, 

Cristina Simo

Radiochemistry and Nuclear Imaging laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, Donostia-San Sebastián, 20014 Spain

Soft Matter Nanotechnology, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, Donostia-San Sebastián, 20014 Spain

Department of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110 USA

Search for more papers by this author
Cristian Salvador, 

Cristian Salvador

Soft Matter Nanotechnology, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, Donostia-San Sebastián, 20014 Spain

CIDETEC, Basque Research and Technology Alliance (BRTA), Parque Científico y Tecnológico de Gipuzkoa, Miramon Pasealekua, 196, Donostia-San Sebastián, 20014 Spain

Search for more papers by this author
Patrizia Andreozzi, 

Patrizia Andreozzi

Consorzio Sistemi a Grande Interfase, Department of Chemistry ‘Ugo Schiff’, University of Florence, Via della Lastruccia 3, FI, Sesto Fiorentino, 50019 Italy

Search for more papers by this author
Vanessa Gomez-Vallejo, 

Vanessa Gomez-Vallejo

Radiochemistry and Nuclear Imaging laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, Donostia-San Sebastián, 20014 Spain

Search for more papers by this author
Gabriela Romero, 

Gabriela Romero

Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, 78249 USA

Search for more papers by this author
Damien Dupin, 

Damien Dupin

CIDETEC, Basque Research and Technology Alliance (BRTA), Parque Científico y Tecnológico de Gipuzkoa, Miramon Pasealekua, 196, Donostia-San Sebastián, 20014 Spain

Search for more papers by this author
Jordi Llop, 

Jordi Llop

Radiochemistry and Nuclear Imaging laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, Donostia-San Sebastián, 20014 Spain

Search for more papers by this author
Sergio E. Moya, 

Sergio E. Moya

Soft Matter Nanotechnology, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, Donostia-San Sebastián, 20014 Spain

Search for more papers by this author
First published: 28 November 2023
https://doi.org/10.1002/smll.202370404

Graphical Abstract

Positron Emission Tomography

Polyplex nanoparticles are prepared by complexation of siRNA and polyamines aimed at gene therapy applications for cancer treatment. The radiolabeled polyplexes are injected intratumorally in lung tumor tissue, resulting in a high retention of the nanoparticles in the malignant tissue. More details can be found in article number 2304326 by Jordi Llop, Sergio E. Moya, and co-workers.

Description unavailable

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.