A Biomimetic Peptide Functions as Specific Extracellular Matrix for Quiescence of Stem Cells against Intervertebral Disc Degeneration (Small 44/2023)
Graphical Abstract
Intervertebral Disc Degeneration
A biomimetic peptide (OAFF) binds to C-X-C motif chemokine receptor 1 (CXCR1) and forms fibrous networks on nucleus pulposus stem cells (NPSCs) for mimicking extracellular matrix formation, which induces NPSCs quiescence and ultimately overcomes obstacle in intradiscal injection therapy. More details can be found in article number 2300578 by Lei Wang, Bo Huang, and co-workers.