Volume 19, Issue 44 2370367
Frontispiece
Free Access

A Biomimetic Peptide Functions as Specific Extracellular Matrix for Quiescence of Stem Cells against Intervertebral Disc Degeneration (Small 44/2023)

Yuan Li

Yuan Li

Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 P. R. China

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Kuo Zhang

Kuo Zhang

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, 100190 P. R. China

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Xuezheng Ai

Xuezheng Ai

Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 P. R. China

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Qingshi Zhang

Qingshi Zhang

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, 100190 P. R. China

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Lu Jiang

Lu Jiang

Clinical Medicine Research Center, Xinqiao Hospital, Army Medical University, Chongqing, 400037 P. R. China

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Jiang Long

Jiang Long

Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 P. R. China

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Huange Xu

Huange Xu

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, 100190 P. R. China

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Chencheng Feng

Chencheng Feng

Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 P. R. China

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Yaqing Zhang

Yaqing Zhang

Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 P. R. China

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Guoke Tang

Guoke Tang

Department of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080 P. R. China

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Fanli Chong

Fanli Chong

Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 P. R. China

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Lei Wang

Lei Wang

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, 100190 P. R. China

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Bo Huang

Bo Huang

Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 P. R. China

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First published: 01 November 2023

Graphical Abstract

Intervertebral Disc Degeneration

A biomimetic peptide (OAFF) binds to C-X-C motif chemokine receptor 1 (CXCR1) and forms fibrous networks on nucleus pulposus stem cells (NPSCs) for mimicking extracellular matrix formation, which induces NPSCs quiescence and ultimately overcomes obstacle in intradiscal injection therapy. More details can be found in article number 2300578 by Lei Wang, Bo Huang, and co-workers.

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