Glioma Therapy: Combination Glioma Therapy Mediated by a Dual-Targeted Delivery System Constructed Using OMCN–PEG–Pep22/DOX (Small 42/2018)
Wenbo Qian
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorMin Qian
Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, 201203 China
Search for more papers by this authorYi Wang
Center for Advanced Low-Dimension Materials, Donghua University, Shanghai, 201620 China
Search for more papers by this authorJianfei Huang
Department of Pathology, Clinical Bio-Bank, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorJian Chen
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorLanchun Ni
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorQingfeng Huang
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorQianqian Liu
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorPeipei Gong
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorShiqiang Hou
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorHui Zhu
Research Centre of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorZhongzheng Jia
Medical Image Centre, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorDandan Shen
Medical Image Centre, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorChanglai Zhu
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001 China
Search for more papers by this authorRui Jiang
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorJunlong Sun
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorJunzhong Yao
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorZhongyu Tang
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorXiang Ji
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorJinlong Shi
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorRongqin Huang
Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, 201203 China
Search for more papers by this authorWei Shi
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorWenbo Qian
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorMin Qian
Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, 201203 China
Search for more papers by this authorYi Wang
Center for Advanced Low-Dimension Materials, Donghua University, Shanghai, 201620 China
Search for more papers by this authorJianfei Huang
Department of Pathology, Clinical Bio-Bank, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorJian Chen
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorLanchun Ni
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorQingfeng Huang
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorQianqian Liu
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorPeipei Gong
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorShiqiang Hou
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorHui Zhu
Research Centre of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorZhongzheng Jia
Medical Image Centre, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorDandan Shen
Medical Image Centre, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorChanglai Zhu
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001 China
Search for more papers by this authorRui Jiang
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorJunlong Sun
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorJunzhong Yao
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorZhongyu Tang
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorXiang Ji
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorJinlong Shi
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorRongqin Huang
Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, 201203 China
Search for more papers by this authorWei Shi
Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001 China
Search for more papers by this authorGraphical Abstract
In article number 1801905, Jinlong Shi, Rongqin Huang, Wei Shi, and co-workers describe a novel drug-loaded system, OPPD, which uses PEG and OMCN linked to the Pep22 polypeptide targeting the low-density lipoprotein receptor, that can effectively cross the blood-brain barrier and target glioma cells, exerting an outstanding therapeutic efficacy via both the near-infrared photothermal and chemotherapeutic effects of the loaded DOX. The collective findings support the utility of OPPD, a promising drug-delivery vehicle, for future clinical application in glioma therapy.
