High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke
Jing Wang
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorHua Zhang
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorDalong Ni
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorWenpei Fan
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorJianxun Qu
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorYanyan Liu
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorYingying Jin
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorZhaowen Cui
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorTianyong Xu
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorYue Wu
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorCorresponding Author
Wenbo Bu
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 P. R. China
E-mail: [email protected], [email protected]Search for more papers by this authorCorresponding Author
Zhenwei Yao
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
E-mail: [email protected], [email protected]Search for more papers by this authorJing Wang
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorHua Zhang
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorDalong Ni
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorWenpei Fan
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorJianxun Qu
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorYanyan Liu
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorYingying Jin
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorZhaowen Cui
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorTianyong Xu
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorYue Wu
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
Search for more papers by this authorCorresponding Author
Wenbo Bu
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 P. R. China
E-mail: [email protected], [email protected]Search for more papers by this authorCorresponding Author
Zhenwei Yao
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
E-mail: [email protected], [email protected]Search for more papers by this authorAbstract
Multimodal magnetic resonance (MR) imaging, including MR angiography (MRA) and MR perfusion (MRP), plays a critical role in the diagnosis and surveillance of acute ischemic stroke. However, these techniques are hindered by the low T1 relaxivity, short circulation time, and high leakage rate from vessels of clinical Magnevist. To address these problems, nontoxic polyethylene glycol (PEG)ylated upconversion nanoprobes (PEG-UCNPs) are synthesized and first adopted for excellent MRA and MRP imaging, featuring high diagnostic sensitivity toward acute ischemic stroke in high-resolution imaging. The investigations show that the agent possesses superior advantages over clinical Magnevist, such as much higher relaxivity, longer circulation time, and lower leakage rate, which guarantee much better imaging efficiency. Remarkably, an extremely small dosage (5 mg Gd kg−1) of PEG-UCNPs provides high-resolution MRA imaging with the vascular system delineated much clearer than the Magnevist with clinical dosage as high as 108 mg Gd kg−1. On the other hand, the long circulation time of PEG-UCNPs enables the surveillance of the progression of ischemic stroke using MRA or MRP. Once translated, these PEG-UCNPs are expected to be a promising candidate for substituting the clinical Magnevist in MRA and MRP, which will significantly lengthen the imaging time window and improve the overall diagnostic efficiency.
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