Multifunctional Upconversion Mesoporous Silica Nanostructures for Dual Modal Imaging and In Vivo Drug Delivery
Chunxia Li
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorDongmei Yang
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorPing'an Ma
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorYinyin Chen
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorYuan Wu
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorZhiyou Hou
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorYunlu Dai
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorJihong Zhao
The Tumor Hospital of Jilin Province, Changchun 130012, P. R. China
Search for more papers by this authorChangping Sui
The Tumor Hospital of Jilin Province, Changchun 130012, P. R. China
Search for more papers by this authorCorresponding Author
Jun Lin
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.Search for more papers by this authorChunxia Li
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorDongmei Yang
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorPing'an Ma
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorYinyin Chen
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorYuan Wu
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorZhiyou Hou
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorYunlu Dai
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
Search for more papers by this authorJihong Zhao
The Tumor Hospital of Jilin Province, Changchun 130012, P. R. China
Search for more papers by this authorChangping Sui
The Tumor Hospital of Jilin Province, Changchun 130012, P. R. China
Search for more papers by this authorCorresponding Author
Jun Lin
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.Search for more papers by this authorAbstract
Incorporating the agents for magnetic resonance imaging (MRI), optical imaging, and therapy in one nanostructured matrix to construct multifunctional nanomedical platform has attracted great attention for simultaneous diagnostic and therapeutic applications. In this work, a facile methodology is developed to construct a multifunctional anticancer drug nanocarrier by combining the special advantages of upconversion nanoparticles and mesoporous silica. β-NaYF4:Yb3+, Er3+@β-NaGdF4:Yb3+ is chosen as it can provide the dual modality of upconversion luminescence and MRI. Then mesoporous silica is directly coated onto the upconversion nanoparticles to form discrete, monodisperse, highly uniform, and core–shell structured nanospheres (labeled as UCNPs@mSiO2), which are subsequently functionalized with hydrophilic polymer poly(ethylene glycol) (PEG) to improve the colloidal stability and biocompatibility. The obtained multifunctional nanocomposites can be used as an anticancer drug delivery carrier and applied for imaging. The anticancer drug doxorubicin (DOX) is absorbed into UCNPs@mSiO2-PEG nanospheres and released in a pH-sensitive pattern. In vitro cell cytotoxicity tests on cancer cells verify that the DOX-loaded UCNPs@mSiO2-PEG has comparable cytotoxicity with free DOX at the same concentration of DOX. In addition, the T1-weighted MRI that measures in aqueous solutions reveals that the contrast brightening increases with the concentration of Gd3+ component. Upconversion luminescence images of UCNPs@mSiO2-PEG uptaken by cells show green emission under 980 nm infrared laser excitation. Finally, the nanocomposites show low systematic toxicity and high in vivo antitumor therapy efficacy. These findings highlight the fascinating features of upconversion-mesoporous nanocomposites as multimodality imaging contrast agents and nanocarrier for drug molecules.
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