The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a
Sarah K. Casper
Department of Biological Sciences, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Department of Health Sciences, Blackhawk Technical College, Janesville, Wisconsin, 53545
Search for more papers by this authorScott J. Schoeller
Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorDanielle M. Zgoba
Department of Biological Sciences, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorAndrew J. Phillips
Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorThomas J. Morien
Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorGary R. Chaffee
Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorPeter C. Sackett
Department of Biological Sciences, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorFrancis C. Peterson
Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226
Search for more papers by this authorCorresponding Author
Kirsten Crossgrove
Department of Biological Sciences, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Correspondence to: Christopher T. Veldkamp, Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190. E-mail: [email protected] and Kirsten Crossgrove, Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190. E-mail: [email protected]Search for more papers by this authorCorresponding Author
Christopher T. Veldkamp
Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226
Correspondence to: Christopher T. Veldkamp, Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190. E-mail: [email protected] and Kirsten Crossgrove, Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190. E-mail: [email protected]Search for more papers by this authorSarah K. Casper
Department of Biological Sciences, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Department of Health Sciences, Blackhawk Technical College, Janesville, Wisconsin, 53545
Search for more papers by this authorScott J. Schoeller
Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorDanielle M. Zgoba
Department of Biological Sciences, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorAndrew J. Phillips
Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorThomas J. Morien
Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorGary R. Chaffee
Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorPeter C. Sackett
Department of Biological Sciences, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Search for more papers by this authorFrancis C. Peterson
Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226
Search for more papers by this authorCorresponding Author
Kirsten Crossgrove
Department of Biological Sciences, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Correspondence to: Christopher T. Veldkamp, Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190. E-mail: [email protected] and Kirsten Crossgrove, Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190. E-mail: [email protected]Search for more papers by this authorCorresponding Author
Christopher T. Veldkamp
Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190
Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226
Correspondence to: Christopher T. Veldkamp, Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190. E-mail: [email protected] and Kirsten Crossgrove, Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190. E-mail: [email protected]Search for more papers by this authorSarah K. Casper and Scott J. Schoeller contributed equally to this work.
ABSTRACT
Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins. Proteins 2014; 82:3490–3496. © 2014 Wiley Periodicals, Inc.
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