Inclusion complexes of estrone and estradiol with β-cyclodextrin: Voltammetric and HPLC studies
Corresponding Author
Claudia Yañez
Organic and Physical Chemistry Department, Chemical and Pharmaceutical Sciences Faculty, University of Chile, Santiago, Chile
Organic and Physical Chemistry Department, Chemical and Pharmaceutical Sciences Faculty, University of Chile, P.O. Box 233 Santiago, Chile.===Search for more papers by this authorJulio Basualdo
Organic and Physical Chemistry Department, Chemical and Pharmaceutical Sciences Faculty, University of Chile, Santiago, Chile
Search for more papers by this authorPaola Jara-Ulloa
Organic and Physical Chemistry Department, Chemical and Pharmaceutical Sciences Faculty, University of Chile, Santiago, Chile
Search for more papers by this authorJ. Arturo Squella
Organic and Physical Chemistry Department, Chemical and Pharmaceutical Sciences Faculty, University of Chile, Santiago, Chile
Search for more papers by this authorCorresponding Author
Claudia Yañez
Organic and Physical Chemistry Department, Chemical and Pharmaceutical Sciences Faculty, University of Chile, Santiago, Chile
Organic and Physical Chemistry Department, Chemical and Pharmaceutical Sciences Faculty, University of Chile, P.O. Box 233 Santiago, Chile.===Search for more papers by this authorJulio Basualdo
Organic and Physical Chemistry Department, Chemical and Pharmaceutical Sciences Faculty, University of Chile, Santiago, Chile
Search for more papers by this authorPaola Jara-Ulloa
Organic and Physical Chemistry Department, Chemical and Pharmaceutical Sciences Faculty, University of Chile, Santiago, Chile
Search for more papers by this authorJ. Arturo Squella
Organic and Physical Chemistry Department, Chemical and Pharmaceutical Sciences Faculty, University of Chile, Santiago, Chile
Search for more papers by this authorAbstract
The interaction of estrone and estradiol with β-cyclodextrins (βCD) was investigated by differential pulse voltammetry (DPV) and high-performance liquid chromatography (HPLC) in mixed media. The co-solvent influence on the tendency of these estrogens to form inclusion complexes with βCD was examined. Thus, acetonitrile (MeCN) and ethanol (EtOH) were used in a mixed aqueous medium containing phosphate buffer. The association constant of the inclusion complexes (Ka) of estrone and estradiol with βCD were determined in two different media by using both voltammetric and chromatographic techniques. Estradiol was found to bind to βCD with higher affinities than estrone, irrespective of the medium. We have also found a clear influence of the co-solvent on the Ka value, which means a competition of co-solvent molecules with estrogens for binding to the cavity of βCD. Consequently, interaction between βCD and the steroids is weakened when acetonitrile is used. Copyright © 2007 John Wiley & Sons, Ltd.
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